INCIDENCE OF INVOLVEMENT OF RETROAREOLAR DISC IN MODIFIED RADICAL MASTECTOMY

Document Type : Preliminary preprint short reports of original research

Authors

1 Department of Surgery, Faculty of Medicine, Alexandria University

2 Service de chirurgie Oncologique et du Sein, Département de chirurgie.

3 Department of Pathology, Faculty of Medicine, Alexandria University.

4 Department of Surgery, Faculty of Medicine, Alexandria University.

Abstract

The retroareolar disc, also known as the nipple-areola complex (NAC), represents a structurally and functionally significant region of the breast anatomy. Situated at the apex of the breast mound, the retroareolar disc encompasses the nipple, areola, and surrounding pigmented skin. This complex structure plays a crucial role in both the aesthetic appearance of the breast and the physiological processes of lactation and nipple sensation
In the context of breast cancer, previous studies have explored the role of retroareolar disc involvement as a prognostic factor and potential site of tumor dissemination. Research findings suggest that retroareolar disc invasion by malignant cells may confer an increased risk of local recurrence and distant metastasis, highlighting the importance of thorough evaluation and targeted therapeutic interventions in affected individuals. Additionally, investigations into the molecular and genetic characteristics of retroareolar disc-associated breast tumors have provided valuable insights into the underlying mechanisms driving disease progression and therapeutic resistance, paving the way for the development of novel targeted therapies and personalized treatment approaches.

Keywords