1Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Alexandria University
2Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Alexandria University.
Abstract
Backgound: Atopic dermatitis is the most common chronic inflammatory skin disorder of childhood. Possible involvement of Th17 in the pathogenesis of AD has been reported by some researchers. Interaction between Th2 type inflammation and skin defects leads to chronic inflammation which is associated with overproduction of reactive oxygen species (ROS) leading to oxidative stress.
Aim: The present study aimed to investigate serum level of inflammatory and oxidative stress markers in childhood AD patients in comparison to healthy controls.
Method: Enzyme-linked immunosorbent assay was used to measure inflammatory and oxidative stress markers level in the sera of 50 children with AD and 50 healthy control children. The Eczema Area and Severity Index (EASI) score was used to determine the severity of the disease.
Results: The mean serum level of inflammatory and oxidative stress markers in children with AD was significantly higher than that in the control group.
Conclusion: This study confirmed the role of inflammatory and oxidative stress markers in atopic dermatitis.
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