PROGNOSTIC VALUE OF CTBP2 AND CASP8AP2 EXPRESSION IN ADULT ACUTE B-CELL LYMPHOBLASTIC LEUKEMIA PATIENTS

Document Type : Preliminary preprint short reports of original research

Authors

1 clinical pathology, faculty of medicine, alexandria university

2 Departments of internal medicine, Hematology, Faculty of Medicine, University of Alexandria, Egypt

3 Department of Physical Medicine, Rheumatology and Rehabilitation, Faculty of medicine, Alexandria university, Egypt.

4 Department of Clinical and Chemical Pathology, Alexandria University, Egypt.

Abstract

Acute lymphoblastic leukemia is a clonal proliferationof the lymphocyte precursor cells. Both T-cell and B-cell precursors can give rise to ALL.Molecular markers have made a breakthrough in ALL after proving to be important in disease pathogenesis and as therapeutic targets. The C-terminal binding protein 2 (CTBP2) is a transcriptional repressor that was reported to correlate with tumorigenesis and progression in several cancers. Down-regulation of CTBP2 mediated by some tumor suppressors results in p53-independent apoptosis and reduced tumor cell migration and invasion. Caspase-8 associated protein 2 (CASP8AP2) has been recognized as a key mediator of apoptosis. Previous studies conducted stated that low expression of CTBP2 and CASP8AP2 gene was associated with relapse in childhood B-ALL. Yet, minimal studies have been conducted to evaluate the prognostic role of CTBP2 and CASP8AP2 gene expression in adult B-ALL.
AIM:
The aim of this study was to investigate the expression of CTBP2 and CASP8AP2 genes in newly diagnosed cases of acute B-cell lymphoblastic leukemia in adult patients in relation with other clinicopathological parameters.

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