swelem, R., Abdelrahman, A., imbaby, S., Ahmed, N. (2024). PROGNOSTIC VALUE OF CTBP2 AND CASP8AP2 EXPRESSION IN ADULT ACUTE B-CELL LYMPHOBLASTIC LEUKEMIA PATIENTS. ALEXMED ePosters, 6(2), 39-40. doi: 10.21608/alexpo.2024.296944.1865
rania shafik swelem; Ahmed Shehata Abdelrahman; salma alaa eldin imbaby; Nourane Khaled Abdellah Ahmed. "PROGNOSTIC VALUE OF CTBP2 AND CASP8AP2 EXPRESSION IN ADULT ACUTE B-CELL LYMPHOBLASTIC LEUKEMIA PATIENTS". ALEXMED ePosters, 6, 2, 2024, 39-40. doi: 10.21608/alexpo.2024.296944.1865
swelem, R., Abdelrahman, A., imbaby, S., Ahmed, N. (2024). 'PROGNOSTIC VALUE OF CTBP2 AND CASP8AP2 EXPRESSION IN ADULT ACUTE B-CELL LYMPHOBLASTIC LEUKEMIA PATIENTS', ALEXMED ePosters, 6(2), pp. 39-40. doi: 10.21608/alexpo.2024.296944.1865
swelem, R., Abdelrahman, A., imbaby, S., Ahmed, N. PROGNOSTIC VALUE OF CTBP2 AND CASP8AP2 EXPRESSION IN ADULT ACUTE B-CELL LYMPHOBLASTIC LEUKEMIA PATIENTS. ALEXMED ePosters, 2024; 6(2): 39-40. doi: 10.21608/alexpo.2024.296944.1865
PROGNOSTIC VALUE OF CTBP2 AND CASP8AP2 EXPRESSION IN ADULT ACUTE B-CELL LYMPHOBLASTIC LEUKEMIA PATIENTS
1clinical pathology, faculty of medicine, alexandria university
2Departments of internal medicine, Hematology, Faculty of Medicine, University of Alexandria, Egypt
3Department of Physical Medicine, Rheumatology and Rehabilitation, Faculty of medicine, Alexandria university, Egypt.
4Department of Clinical and Chemical Pathology, Alexandria University, Egypt.
Abstract
Acute lymphoblastic leukemia is a clonal proliferationof the lymphocyte precursor cells. Both T-cell and B-cell precursors can give rise to ALL.Molecular markers have made a breakthrough in ALL after proving to be important in disease pathogenesis and as therapeutic targets. The C-terminal binding protein 2 (CTBP2) is a transcriptional repressor that was reported to correlate with tumorigenesis and progression in several cancers. Down-regulation of CTBP2 mediated by some tumor suppressors results in p53-independent apoptosis and reduced tumor cell migration and invasion. Caspase-8 associated protein 2 (CASP8AP2) has been recognized as a key mediator of apoptosis. Previous studies conducted stated that low expression of CTBP2 and CASP8AP2 gene was associated with relapse in childhood B-ALL. Yet, minimal studies have been conducted to evaluate the prognostic role of CTBP2 and CASP8AP2 gene expression in adult B-ALL. AIM: The aim of this study was to investigate the expression of CTBP2 and CASP8AP2 genes in newly diagnosed cases of acute B-cell lymphoblastic leukemia in adult patients in relation with other clinicopathological parameters.
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