EFFECT OF VAGINAL SILDENAFIL ON THE ENDOMETRIUM OF CLOMIPHENE CITRATE INDUCED PATIENTS.

Abd Aldayem, Tamer; Toppozada, Tarek Mokhtar; Eid Ramadan Syam, Lamia Fathy

doi:10.21608/alexpo.2024.259408.1757

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	EFFECT OF VAGINAL SILDENAFIL ON THE ENDOMETRIUM OF CLOMIPHENE CITRATE INDUCED PATIENTS.
Article 1, Volume 6, Issue 1, January 2024, Page 2-3
Document Type: Preliminary preprint short reports of original research
DOI: 10.21608/alexpo.2024.259408.1757
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Authors
Tamer Abd Aldayem¹; Tarek Mokhtar Toppozada²; Lamia Fathy Eid Ramadan Syam ³
¹Obstetric and Gynecology department, faculty of Medicine, Alexandria University, Alexandria
²Department of Obstetrics and Gynecology, Alexandria Faculty of Medicine, Alexandria University
³Department of Obstetrics and Gynecology, Faculty of Medicine, Alexandria University
Abstract
Sufficient endometrial thickness is markedly essentialfor occurrence of successful implantation and pregnancy continuation.Adequate uterine blood flow is necessary for endometrial growth, and it is hormonal dependent.Clomiphene citrate is first drug of choice for ovulation induction in PCOS women.Clomiphene citrate has anti-estrogenic effect onendometrial development and leads to diminish endometrial blood flow.Sildenafil citrate is a specific type of phosphodiesterase inhibitor 5, improves the vasodilatation effects of nitric oxide (NO) on blood vessels and smooth muscle.Sildenafil citrate boosts estrogen-induced endometrial growth and can improve uterine blood flow. Aime of the work: The current study aimed to evaluate efficacy of vaginal sildenafil citrate during ovulation induction with clomiphene in PCOS women as regards endometrial thicknessand pregnancy rate. Patients and methods:Prospective case-control study was conducted on 80 PCOS patients attending infertility clinic at El Shatby University Hospital of Alexandria University.The patients were randomly divided into two groups. Sildenafil group (40patients) received 50mg clomiphene twice daily, and vaginal sildenafil 50mg twice daily. Control (40pt) received 50mg clomiphene alone.Transvaginalultrasound assessment of the endometrium was when one dominant follicle reached size more than 18mm in diameter. Recording the clinical pregnancy rate was done.
Keywords
SILDENAFIL; CLOMIPHENE; PCOS
Supplementary Files 1757 Lamia Fathy Eid Ramadan Syam.pdf

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