COMPARING DIFFERENT EQUATIONS FOR GLOMERULAR FILTERATION RATE CALCULATION IN AN EGYPTIAN ELDERLY POPULATION

Document Type : Preliminary preprint short reports of original research

Authors

1 Department of Internal Medicine, Faculty of Medicine, University of Alexandria.

2 Department of Internal Medicine, Faculty of Medicine, University of Alexandria, Egypt

Abstract

INTRODUCTION:
Chronic kidney disease (CKD) is an important epidemic and public health problem, resulting in end-stage renal disease (ESRD) and increased risk of morbidity and mortality.
CKD is common in elderly individuals, and there is a debate about the accuracy of GFR estimates in this important subgroup of the population.
Accordingly, the present study compared six different GFR estimating equations [MDRD, Cockcroft–Gault–BSA, CKD-EPI (creatinine) CKD-EPI (cystatin C), BIS-1, and BIS-2] in a cohort of Egyptian elderly population.

AIM OF THE WORK:
This work aims at comparing different equations with measured GFR in cohort of Egyptian elderly population.

SUBJECTS AND METHODS:
One hundred patients were included in the study to compare different equations of measured GFR in a cohort of Egyptian elderly population. They were 65 years or older and were recruited from the wards of the internal medicine department of Alexandria Main University Hospital.
Patients in the study were divided according to eGFR estimated by CKD-EPI equation based on the most recent creatinine measured into four groups:
Group 1: stage 2 CKD
Group 2: stage 3 CKD
Group 3: stage 4 CKD
Group 4: stage 5 CKD not on heamodialysis

Keywords