KIDNEY INJURY MOLECULE-1 AND FRACTIONAL EXCRETION OF UREA IN ACUTE RENAL IMPAIRMENT IN HCV DECOMPENSATED CIRRHOSIS

Document Type : Preliminary preprint short reports of original research

Authors

1 Department of Tropical Medicine, Faculty of Medicine, Alexandria University

2 Tropical Medicine Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt

3 Department of Medical Biochemistry, Faculty of Medicine, Alexandria University

Abstract

Acute kidney injury (AKI) is a frequent and serious complication in cirrhosis, particularly in Egypt where HCV is a leading cause. Conventional markers like creatinine are unreliable in cirrhotic patientsdue to altered hepatic metabolism, muscle wasting, and the use of diuretics. This has highlighted the need for novel biomarkers that improve diagnostic accuracy and allow earlier detection of renal injury. Urinary kidney injury molecule-1 (KIM-1) and the fractional excretion of urea (FEUrea) have emerged as promising tools, but their performance in HCV-related cirrhosis remains underexplored.

Aim:

This study aimed to evaluate the diagnostic performance of urinary KIM-1 and FEUrea in detecting and characterizing AKI in patients with HCV-related cirrhosis, and to assess their relationship with liver disease severity scores.

Patients and Methods

Eighty-five participants were studied: 35 cirrhotics with AKI, 35 without AKI, and 15 controls. Urinary KIM-1 was measured by ELISA, and FEUrea calculated from urine/serum urea. Liver disease severity was assessed by Child-Pugh, MELD, and MELD-Na scores. Biomarker levels were compared across groups, with ROC analysis for diagnostic accuracy and evaluation of AKI subtypes.

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