THE IMPACT OF PLATELET RICH PLASMA (PRP) ON THE HEALING OF THE OPERATIVE CAVITY AFTER ENDOSCOPIC SINONASAL SURGERIES

Document Type : Preliminary preprint short reports of original research

Authors

1 Department of Otorhinolaryngology, Faculty of Medicine - University of Alexandria

2 Department of Clinical & Chemical Pathology, Faculty of Medicine - University of Alexandria

3 Department of Histology and Cell Biology, Faculty of Medicine, Alexandria University.

Abstract

The role of endoscopic sinus surgery (ESS) in chronic rhinosinusitis (CRS) refractory to medical treatment is well established in providing symptomatic relief and improvements in quality of life. Postoperative wound healing plays a critical role in producing a successful result after functional endoscopic sinus surgery (FESS). The degree of inflammation within the middle meatus is critical and can influence scar tissue formation and therefore synechiae, which tend to occur between the middle turbinate and lateral nasal wall. Despite advancements in technology and training, the formation of synechiae continues to remain one of the most common causes of surgical failure in FESS, with an incidence of up to 27%.Platelet rich plasma is widely used in various surgical fields, including head and neck surgery, otolaryngology, cardiovascular surgery, and maxillofacial surgery. Commonly used in a gel form which is formed by mixing PRP (derived from the centrifugation of autologus whole blood) with thrombin and calcium chloride.



AIM OF THE WORK:

The present work aims are assessing the role of platelates rich plasma (PRP) on post-operative symptoms, endoscopic findings and histopathological sinus tissue wound healing after FESS at 4, 12 week post-operative.

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