STUDY OF FECAL CALPROTECTIN AS A NON-INVASIVE MARKER ASSOCIATED WITH DISEASE ACTIVITY IN CHRONIC GASTRITIS ADULT PATIENTS

Document Type : Preliminary preprint short reports of original research

Authors

1 Department of Internal Medicine, Faculty of Medicine, Alexandria University

2 Department of Internal Medicine, Gastroenterology Unit, Faculty of Medicine, University of Alexandria

3 Department of Clinical and Chemical Pathology3, Faculty of Medicine, Alexandria University

4 Department of Pathology, Faculty of Medicine, Alexandria University

Abstract

Chronic gastritis is the most common finding at endoscopy in the general population of Eastern countries. It’s an inflammatory process characterized by variable inflammatory cellular infiltrate in the lamina propria, and within the foveolar lumen. Its clinical significance is under estimated although its role in occurrence of peptic ulcer disease and gastric adenocarcinoma is very clear. Helicobacter pylori infection is the most common cause of chronic active gastritis worldwide. The gold standard method for diagnosis of chronic gastritis, especially H.pylori infection related type, is endoscopy with histopathological evaluation of gastric biopsies. Fecal calprotectin is a well established biomarker for gastrointestinal inflammation. It is commonly used to differentiate between irritable bowel syndrome and IBD. The level of calprotectin in fecal matter is quantitatively related to the rate of neutrophil migration into gastrointetstinal wall. There are very few studies that investigated the relation between fecal calprotectin and upper gastrointestinal diseases including chronic gastritis.



AIM OF THE WORK:

The aim of our study was to measure fecal calprotectin levels in patients with chronic gastritis and correlate those levels with gastritis activity score according to the updated Sydney System for gastritis grading and classification.

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