ASSESSMENT OF SEDATION ADEQUACY AMONG CRITICALLY ILL PATIENTS IN ALEXANDRIA MAIN UNIVERSITY HOSPITAL

Document Type : Preliminary preprint short reports of original research

Authors

1 Department of Critical Care Medicine, Faculty of Medicine, Alexandria University

2 Department of Critical Care, Faculty of Medicine, Alexandria University

Abstract

Sedation is defined as the administration of pharmacological agents to attenuate irritability or agitation, thereby facilitating therapeutic or diagnostic procedures as mechanical ventilation. Sedation exerts significant effects on various physiological systems. Sedative pharmacological agents primarily target neurotransmitter pathways within the CNS to inhibit neuronal activity and diminish arousal levels. Over-sedation is associated with extended durations of mechanical ventilation, a higher risk of ventilator-associated pneumonia (VAP), also in delays in weaning from respiratory support. Conversely, inadequate sedation may result in patient agitation and distress, potentially precipitating hazardous behaviors such as self-extubation or inadvertent removal of intravenous lines and catheters. Additionally, agitated patients are more likely to experience psychological trauma. Sedation is also an integral part of the ICU liberation bundle which takes an approach to managing pain, delirium and agitation in critically ill patients to facilitate ventilator weaning and early mobilization and also promotes patient and family engagement in the process making it most effective.

AIM OF THE WORK
The aim of this work was to perform a survey of the sedation adequacy of intensive care patients in Alexandria main university hospital according to Richmond Agitation Sedation scale and to assess its effect on the duration of mechanical ventilation days and duration of ICU stay.

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