ASSESSMENT OF THE SAFETY, EFFICACY AND VERSATILITY OF MODIFIED DEL NIDO CARDIOPLEGIA

Document Type : Preliminary preprint short reports of original research

Authors

1 Assistant professor of Cardiothoracic Surgery, Faculty of Medicine, Alexandria University.

2 professor of Cardiothoracic Surgery, Faculty of Medicine, Alexandria University.

3 Hepatobiliarypancreatic unit, Surgery department, Faculty of medicine, Alexandria university

4 Lecturer of Cardiothoracic Surgery, Faculty of Medicine, Alexandria University

5 Lecturer of anathesia and postoperative ICU Anathesia Department Alexandria University

6 Department of Cardiothoracic Surgery, Faculty of Medicine, Alexandria University

Abstract

Introduction
Cardiovascular diseases (CVDs) are the leading cause of death and disability world wide .
During cardiac surgery, it is imperative for the heart to be non-beating and a blood-free field . The easiest way to achieve this is clamping the aorta by aortic cross clamp and redirecting the circulation to the heart–lung machine . Halting the heart's activity reduces metabolic demands, revolutionizing cardiac operations for enhanced safety and control. The heart's vulnerability during this critical period underscores the importance of effective myocardial protection.
Myocardial injury during cardiac surgery is the leading cause of post-operative morbidity and significant mortality, so that myocardial protection methods are important .Those methods can be enumerated as ; hypothermia , the use of refrigerated saline in the pericadial sac and cardioplegia solution.

Cardioplegic solution is the corner stone of myocardial protection there are 2 primary types of cardioplegia solutions: crystalloid cardioplegia and basic solutions that comprise the constituents of blood.
Del Nido cardioplegia was developed by Dr. Pedro J. del Nido, a pediatric cardiac surgeon, in the early 1990s.

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