PREDICTIVE VALUE OF SERUM INTERLEUKIN-6 TO DETERMINE CORONARY ARTERY DISEASE IN INTERMEDIATE CARDIOVASCULAR RISK INDIVIDUALS .

Document Type : Preliminary preprint short reports of original research

Authors

1 Department of Cardiology and Angiology, Faculty of Medicine- Alexandria University

2 Department of Cardiology and Angiology, Faculty of Medicine, Alexandria University

3 Department of Experimental and Clinical Internal Medicine, Medical Research Institute,* Alexandria University

Abstract

INTRODUCTION:
Coronary artery disease (CAD) among non-communicable diseases is the leading cause of cardiovascular mortality worldwide, with more than 4.5 million deaths occurring in the developing world.The precision in estimating the risk for future CAD is crucial for treatment decision and prevention strategies. It is crucial to improve accuracy in risk prediction for patients with intermediate cardiovascular risk, as calibration is limited when using global risk score calculators. The 2013 ACC/AHA guidelines currently suggest the use of a 10-year ASCVD risk score for estimating the risk of future coronary events and for identifying primary prevention strategies.
Despite the importance of this approach, the precision in patients with intermediate coronary risk is less precise than in higher or lower risk categories.Increased levels of inflammatory agents, including IL-6, have been reported as been associated with acute ischemic conditions and are predictors of recurrent events in patients with CAD.
AIM OF THE WORK:
The aim of this study was to analyze the predictive value of IL-6 for diagnosis of Coronary artery disease (CAD) and correlating the results with extent of CAD using Gensini score in intermediate-risk patients with chest pain.

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