EFFECT OF VITAMIN D SUPPLEMENTATION ON LIPID PROFILE AND GLYCEMIC CONTROL IN TYPE 2 DIABETICS WITH UNTREATED DYSLIPIDEMIA

Document Type : Preliminary preprint short reports of original research

Authors

1 Professor of Internal Medicine, Faculty of Medicine, Alexandria University.

2 Lecturer of Internal Medicine, Faculty of Medicine, Alexandria University.

3 Alexandria university hospital, clinical and chemical pathology, Alexandria, Egypt

4 Department of Internal Medicine, Faculty of Medicine, Alexandria University

Abstract

Introduction:
Vitamin D, a secosteroid hormone, is well known for its roles in calcium metabolism, bone health, and immune system modulation. Emerging evidence suggests that vitamin D may modulate metabolic processes, especially insulin sensitivity and lipid metabolism, through its nuclear receptor (VDR) found in pancreatic β-cells, adipocytes, vascular endothelium, and skeletal muscle. Type 2 Diabetes Mellitus (T2DM) persists as a global health problem. Often associated with dyslipidaemia, this raises the risk of cardiovascular disease substantially. Vitamin D deficiency is prevalent among Egyptian adults, owing to limited sun exposure, sedentary lifestyles, and inadequate dietary intake. The aim of this study is to determine whether high doses vitamin D supplementation to vitamin D deficient subjects with uncontrolled T2DM and untreated dyslipidaemia could improve their lipid profiles and glycaemic control. Understanding these interactions is critical in order toop timise therapeutic strategies and reduce the cardiovascular morbidity and mortality in this high-risk population.

AIM OF THE WORK
The aim of this study was to evaluate the effect of vitamin D supplementation on:
Plasma lipid profile, atherogenic index and glycemic control (Fasting blood glucose, HbA1C) in patients with type 2 diabetes mellitus with associated untreated dyslipidemia and vitamin D deficiency.

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