ANION GAP VALUE AS A PREDICTOR OF SHORT-TERM MORTALITY IN CRITICALLY ILL PATIENTS WITH ACUTE KIDNEY INJURY

Document Type : Preliminary preprint short reports of original research

Authors

1 Department of Surgery , faculty of medicine , Alexandria university

2 Department of Internal Medicin, Faculty of Medicine, University of Alexandria. Egypt

3 Department of Emergency Medicine3, Faculty of Medicine, Alexandria University

4 Department of Emergency Medicine, Faculty of Medicine, Alexandria University

Abstract

Introduction
Acute Kidney Injury (AKI) is a common and potentially reversible condition marked by a sudden decline in renal function, often detected through reduced glomerular filtration rate (GFR). According to KDIGO, AKI is diagnosed by a rise in serum creatinine or reduced urine output. It is classified into prerenal, intrinsic, and postrenal causes. Sepsis remains the most frequent trigger, with AKI pathophysiology involving both structural damage and functional impairment.
Effective management requires close monitoring of renal function and fluid balance, withdrawal of nephrotoxins, dietary adjustments, and, when needed, dialysis. Metabolic acidosis is a frequent complication, especially in critically ill patients, and may present with a high or normal anion gap. The anion gap (AG), a key diagnostic tool, also has prognostic value. Correcting AG for hypoalbuminemia improves accuracy. Management of high AG acidosis targets the underlying cause, with alkalinization reserved for severe acidemia (pH < 7.1).

AIM OF THE WORK
This study investigated the prognostic significance of admission anion gap levels in predicting mortality among critically ill patients with acute kidney injury.

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