THE ROLE OF MICRORNA-142 AND TRANSFORMING GROWTH FACTOR-BETA IN OBESITY-INDUCED ERECTILE DYSFUNCTION IN RATS

Document Type : Preliminary preprint short reports of original research

Authors

1 Department of Dermatology, Venereology, and Andrology Faculty of Medicine, Alexandria University.

2 Department of Medical Physiology2, Faculty of Medicine, Alexandria University

3 Dermatology, Venereology and Andrology, Faculty of Medicine, Alexandria University.

4 Department of Pathology, Alexandria Faculty of Medicine, Alexandria University

5 Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Alexandria University

Abstract

-Introduction
Erectile dysfunction (ED) is the persistent inability to achieve and/or maintain an erection firm enough for satisfactory sexual intercourse. Millions of men worldwide are affected with an estimate of 322 million men in 2025. Evidence from animal to human research supports the association between obesity and ED, with all the known obesity indices already linked to ED.

MiRNAs have already been established as biomarkers in many diseases. And hence their levels are disturbed in both ED and obesity, there are high hopes for them to act as biomarkers in those diseases too. MiRNA-142 came to the light repeatedly in both obesity and ED research but with not enough data on its level or role in obesity-induced ED. TGF-β was proven to play a role in ED through the induction of cavernous fibrosis. Similarly, elevated levels of TGF-β have been linked to obesity and high BMI.
-Aim
To assess the role of miRNA-142 and TGF-β in pathogenesis of obesity-induced erectile dysfunction in rat model fed with high fat diet.

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