EFFICACY OF ACETAZOLAMIDE IN MANAGEMENT OF ACUTE DECOMPENSATED HEART FAILURE WITH VOLUME OVERLOAD

Document Type : Preliminary preprint short reports of original research

Authors

1 Critical Care Medicine Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt

2 Critical Care Medicine Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.

3 Department of Critical Care Medicine

4 faculty of medicine, alexandria university, cardiology and angiology department

5 Department of Critical Care Medicine, Alexandria University

Abstract

Heart failure (HF) is a major global health concern, affecting 1–3% of the adult population and leading to frequent hospital admissions. Acute decompensated heart failure (ADHF) is a life-threatening condition marked by rapid worsening of chronic HF symptoms, commonly associated with volume overload. Despite advancements in therapy, ADHF remains a major clinical challenge. Traditional treatment includes loop diuretics to relieve fluid overload. However, diuretic resistance and adverse effects on renal function limit their efficacy. Acetazolamide, a carbonic anhydrase inhibitor with diuretic properties, has emerged as a potential adjunct therapy to improve decongestion without worsening kidney function. This study investigates the impact of adding acetazolamide to standard loop diuretic therapy in managing volume overload among patients with ADHF and reduced ejection fraction.

AIM OF THE WORK:
The aim of this study was to assess whether the addition of acetazolamide to loop diuretics improves decongestion in patients with acute decompensated heart failure with volume overload.

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