EVALUATION OF EFFICACY OF FOLLICULAR UNIT EXCISION VERSUS FOLLICULAR UNIT EXCISION WITH NANOFAT IN SCARS IN HAIRY AREAS

Document Type : Preliminary preprint short reports of original research

Authors

1 Plastic Surgery Unit, Surgery Department, Faculty of Medicine, Alexandria University.

2 Department of Plastic Surgery Unit, Faculty of Medicine, Alexandria University

Abstract

Scars can result in significant changes in appearance that cause negative impact on the image as well as the self-confidence. scars serve as constant reminders of trauma, reinforcing feelings of devaluation, leading to functional impairments that may necessitate career changes and result in financial strain, and emotionally individuals with visible scars often experience a shift in their psychological state, making them more susceptible to depression and anxiety.
Nanofat reduces inflammation, stimulates angiogenesis, and modifies the behavior of surrounding cells. Nanofat injections increase collagen organization, decrease fibrosis markers and improve expression of antifibrotic factors. Nanofat stem cells (NCS) exhibit immunomodulatory effects, suppressing lymphocyte proliferation and inhibiting the activities of proinflammatory cells contributing to dermal fibrosis improvement. The potential benefits of nanofat include its capability of remodeling the ECM in the dermal layer, promoting dermal fibroblasts and epidermal keratinocytes to proliferate and migrate, and promote the secretion of ECM proteins. So Nanofat showed significant increases in collagen deposition, epidermal thickness, and other positive changes, supporting the effectiveness of micro-fat injection in scar characteristics such as vascularity, thickness, pliability, relief, surface area, stiffness, and irregularity.
Nanofat has been documented in the literature as a valuable method to inducematuration &improvement of scars owing to the small size of particle and high stem cell content. Barr and Barrera (2011) suggested that fat grafting before hair follicle placement enhances graft survival and promotes optimal growth in previously compromised tissue.

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