CEREBROSPINAL FLUID NUCLEOTIDE-BINDING DOMAIN LEUCINE-RICH REPEAT PYRIN DOMAIN CONTAINING3 AS DIAGNOSTIC MARKER OF BACTERIAL MENINGITIS

Document Type : Preliminary preprint short reports of original research

Authors

1 Department of Tropical Medicine, Faculty of Medicine, Alexandria University

2 Department of Tropical Medicine, Faculty of Medicine Alexandria University

3 Medical Microbiology and Immunology, Faculty of Medicine Alexandria University

4 Damanhur Fever Hospital, Department of Critical Cases, Faculty of Medicine, Alexandria University

Abstract

INTRODUCTION:
Meningitisis a life-threatening which characterized by inflammation of the meninges, which are membranes that cover the brain and spinal cord. The disease can spread worldwide but is more common in certain regions and endemic in Egypt.Both bacteria and viruses can cause meningitis. Bacterial meningitis is more dangerous than viral meningitis Inflammasomes are Intracellular multiprotein complexes linked to inflammatory reactions, which operate as a link between inflammatory and immunological responses.Of all the inflammasome types, the NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasomes are implicated in the etiology and development of a number of immunological and inflammation-related conditions, including diseases of the central nervous system (CNS).Our study demonstrate that during bacterial meningitis, NLRP3 may have some significant pathophysiological impacts ascerebral edema, Microvascular injury, neurological injury, CSF pleocytosis, and necrotic cell death in oligodendroglia have all been linked to these inflammasomes.
AIM OF THE WORK:
The aims of this study was to evaluate the role of CSF NLRP3 level as diagnostic marker for bacterial meningitis.

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