VALIDATION OF NOVEL SEPSIS SUB-PHENOTYPES USING TRAJECTORIES OF VITAL SIGNS AT ALEXANDRIA PEDIATRIC INTENSIVE CARE UNIT

Document Type : Preliminary preprint short reports of original research

Authors

1 Department of Pediatric, Faculty of Medicine, Alexandria University, Egypt

2 Department of Pediatrics, Faculty of Medicine, Alexandria University

Abstract

Introduction
Sepsis is a major global health threat, particularly for children, contributing to significant morbidity and mortality. The WHO recognizes it as a leading cause of death in pediatric intensive care units (PICUs), with mortality rates exceeding 50% in developing countries.
Sepsis is caused by an abnormal immune response to infection, leading to life-threatening organ dysfunction. Early diagnosis and treatment are essential for improving outcomes.
Recent studies suggest that identifying sub-phenotypes could enable more personalized management strategies. These sub-phenotypes may display distinct baseline characteristics, laboratory abnormalities, and patterns of organ dysfunction. However, data on sepsis remains limited, and understanding of its sub-phenotypes—distinct classifications based on responses to treatment—remains incomplete and are areas of ongoing research. Identifying these sub-phenotypes could improve diagnosis, intervention timing, and monitoring.
Aim of the work
This study aims to validate novel sepsis sub-phenotyping based on vital signs trajectories in pediatric severe sepsis and correlate these sub-phenotypes with clinical outcomes, complications, PICU stay length, and mechanical ventilation need.

Keywords

ALEXMED ePosters
Volume 7, Issue 1
January 2025
Pages 29-30

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