Ramadan, M., abdelmalak, M., Alhinai, A. (2025). VALIDATION OF NOVEL SEPSIS SUB-PHENOTYPES USING TRAJECTORIES OF VITAL SIGNS AT ALEXANDRIA PEDIATRIC INTENSIVE CARE UNIT. ALEXMED ePosters, 7(1), 29-30. doi: 10.21608/alexpo.2025.358294.2084
magdy abdelfatah Ramadan; Manal abdelmalak; Ashley Hassan Alhinai. "VALIDATION OF NOVEL SEPSIS SUB-PHENOTYPES USING TRAJECTORIES OF VITAL SIGNS AT ALEXANDRIA PEDIATRIC INTENSIVE CARE UNIT". ALEXMED ePosters, 7, 1, 2025, 29-30. doi: 10.21608/alexpo.2025.358294.2084
Ramadan, M., abdelmalak, M., Alhinai, A. (2025). 'VALIDATION OF NOVEL SEPSIS SUB-PHENOTYPES USING TRAJECTORIES OF VITAL SIGNS AT ALEXANDRIA PEDIATRIC INTENSIVE CARE UNIT', ALEXMED ePosters, 7(1), pp. 29-30. doi: 10.21608/alexpo.2025.358294.2084
Ramadan, M., abdelmalak, M., Alhinai, A. VALIDATION OF NOVEL SEPSIS SUB-PHENOTYPES USING TRAJECTORIES OF VITAL SIGNS AT ALEXANDRIA PEDIATRIC INTENSIVE CARE UNIT. ALEXMED ePosters, 2025; 7(1): 29-30. doi: 10.21608/alexpo.2025.358294.2084
VALIDATION OF NOVEL SEPSIS SUB-PHENOTYPES USING TRAJECTORIES OF VITAL SIGNS AT ALEXANDRIA PEDIATRIC INTENSIVE CARE UNIT
1Department of Pediatric, Faculty of Medicine, Alexandria University, Egypt
2Department of Pediatrics, Faculty of Medicine, Alexandria University
Abstract
Introduction Sepsis is a major global health threat, particularly for children, contributing to significant morbidity and mortality. The WHO recognizes it as a leading cause of death in pediatric intensive care units (PICUs), with mortality rates exceeding 50% in developing countries. Sepsis is caused by an abnormal immune response to infection, leading to life-threatening organ dysfunction. Early diagnosis and treatment are essential for improving outcomes. Recent studies suggest that identifying sub-phenotypes could enable more personalized management strategies. These sub-phenotypes may display distinct baseline characteristics, laboratory abnormalities, and patterns of organ dysfunction. However, data on sepsis remains limited, and understanding of its sub-phenotypes—distinct classifications based on responses to treatment—remains incomplete and are areas of ongoing research. Identifying these sub-phenotypes could improve diagnosis, intervention timing, and monitoring. Aim of the work This study aims to validate novel sepsis sub-phenotyping based on vital signs trajectories in pediatric severe sepsis and correlate these sub-phenotypes with clinical outcomes, complications, PICU stay length, and mechanical ventilation need.
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