ROLE OF CIRCULAR RIBONUCLEIC ACID COILED-COIL DOMAIN CONTAINING 66 AND SERINE/THREONINE KINASE-2 IN PATHOGENESIS OF CROHN’S DISEASE

Document Type : Preliminary preprint short reports of original research

Authors

1 Department of Medical Biochemistry, Faculty of Medicine, Alexandria University.

2 Department of Internal Medicine, Faculty of Medicine, Alexandria University.

Abstract

Crohn's disease (CD) is a chronic and relapsing inflammatory bowel disease affecting GIT. Circular RNAs (CircRNAs) are non-coding RNAs produced in mammals through back splicing. They have advantages over linear RNAs in stability and resistance, so they have the potential to be used as both therapeutic targets and diagnostic biomarkers. CircRNAs are thought to regulate autophagy and inflammation. Circular RNA CCDC66 (circCCDC66) in CD are not well characterized, and their functions are not well understood. Thus, it is crucial to investigate its role in this disease.CircCCDC66 is thought to regulate inflammation and it has been identified as a novel oncogenic circRNA. CircCCDC66 is thought to contribute to colorectal cancer via upregulating the expression of autophagy related serine/threonine kinase 2 (AKT2) by sponging micro RNA-510-5p and regulate autophagy. Because autophagy may play a role in CD pathogenesis, circCCDC66 may also contribute to CD development by regulating AKT-2.
AIM OF THE WORK:
The aim of this study was to evaluate the role of circCCDC66 and circulating AKT-2 in the pathogenesis of CD, as well as to identify the relationship between circCCDC66 expression and circulating autophagy-related AKT-2 and disease activity of CD patients. Additionally, it aimed to test the possibility of using circulating circCCDC66 as a potential promising non-invasive biomarker for CD.

Keywords

ALEXMED ePosters
Volume 7, Issue 1
January 2025
Pages 24-25

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