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Shaat, E., Nounou, H., mahmoud, A., Soliman, N., Desouky, H. (2025). ROLE OF CIRCULAR RIBONUCLEIC ACID COILED-COIL DOMAIN CONTAINING 66 AND SERINE/THREONINE KINASE-2 IN PATHOGENESIS OF CROHN’S DISEASE. ALEXMED ePosters, 7(1), 24-25. doi: 10.21608/alexpo.2025.357121.2075
Eman Ahmed Fathi Shaat; Howaida Attia Aly Nounou; Abeer mahmoud; Nada Ahmed Hussein Soliman; Heba Allah Mohamed Naguib Desouky. "ROLE OF CIRCULAR RIBONUCLEIC ACID COILED-COIL DOMAIN CONTAINING 66 AND SERINE/THREONINE KINASE-2 IN PATHOGENESIS OF CROHN’S DISEASE". ALEXMED ePosters, 7, 1, 2025, 24-25. doi: 10.21608/alexpo.2025.357121.2075
Shaat, E., Nounou, H., mahmoud, A., Soliman, N., Desouky, H. (2025). 'ROLE OF CIRCULAR RIBONUCLEIC ACID COILED-COIL DOMAIN CONTAINING 66 AND SERINE/THREONINE KINASE-2 IN PATHOGENESIS OF CROHN’S DISEASE', ALEXMED ePosters, 7(1), pp. 24-25. doi: 10.21608/alexpo.2025.357121.2075
Shaat, E., Nounou, H., mahmoud, A., Soliman, N., Desouky, H. ROLE OF CIRCULAR RIBONUCLEIC ACID COILED-COIL DOMAIN CONTAINING 66 AND SERINE/THREONINE KINASE-2 IN PATHOGENESIS OF CROHN’S DISEASE. ALEXMED ePosters, 2025; 7(1): 24-25. doi: 10.21608/alexpo.2025.357121.2075

ROLE OF CIRCULAR RIBONUCLEIC ACID COILED-COIL DOMAIN CONTAINING 66 AND SERINE/THREONINE KINASE-2 IN PATHOGENESIS OF CROHN’S DISEASE

Article 1, Volume 7, Issue 1, January 2025, Page 24-25  XML
Document Type: Preliminary preprint short reports of original research
DOI: 10.21608/alexpo.2025.357121.2075
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Authors
Eman Ahmed Fathi Shaat1; Howaida Attia Aly Nounou1; Abeer mahmoud2; Nada Ahmed Hussein Soliman1; Heba Allah Mohamed Naguib Desouky email 1
1Department of Medical Biochemistry, Faculty of Medicine, Alexandria University.
2Department of Internal Medicine, Faculty of Medicine, Alexandria University.
Abstract
Crohn's disease (CD) is a chronic and relapsing inflammatory bowel disease affecting GIT. Circular RNAs (CircRNAs) are non-coding RNAs produced in mammals through back splicing. They have advantages over linear RNAs in stability and resistance, so they have the potential to be used as both therapeutic targets and diagnostic biomarkers. CircRNAs are thought to regulate autophagy and inflammation. Circular RNA CCDC66 (circCCDC66) in CD are not well characterized, and their functions are not well understood. Thus, it is crucial to investigate its role in this disease.CircCCDC66 is thought to regulate inflammation and it has been identified as a novel oncogenic circRNA. CircCCDC66 is thought to contribute to colorectal cancer via upregulating the expression of autophagy related serine/threonine kinase 2 (AKT2) by sponging micro RNA-510-5p and regulate autophagy. Because autophagy may play a role in CD pathogenesis, circCCDC66 may also contribute to CD development by regulating AKT-2.
AIM OF THE WORK:
The aim of this study was to evaluate the role of circCCDC66 and circulating AKT-2 in the pathogenesis of CD, as well as to identify the relationship between circCCDC66 expression and circulating autophagy-related AKT-2 and disease activity of CD patients. Additionally, it aimed to test the possibility of using circulating circCCDC66 as a potential promising non-invasive biomarker for CD.
Keywords
Crohn's disease (CD); circCCDC66; AKT2
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