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Morsy, E., Amin, N., Kassab, H., Ali Khalifa Mostafa, R. (2025). URINARY C PEPTIDE/ CREATININE RATIO AND ITS RELATION TO INSULIN RESISTANCE AND VASCULAR COMPLICATIONS IN TYPE 2 DIABETES. ALEXMED ePosters, 7(1), 8-9. doi: 10.21608/alexpo.2025.352132.2063
Eman Youssef Morsy; Noha Amin; Heba Sadek Kassab; Rowan Khalifa Ali Khalifa Mostafa. "URINARY C PEPTIDE/ CREATININE RATIO AND ITS RELATION TO INSULIN RESISTANCE AND VASCULAR COMPLICATIONS IN TYPE 2 DIABETES". ALEXMED ePosters, 7, 1, 2025, 8-9. doi: 10.21608/alexpo.2025.352132.2063
Morsy, E., Amin, N., Kassab, H., Ali Khalifa Mostafa, R. (2025). 'URINARY C PEPTIDE/ CREATININE RATIO AND ITS RELATION TO INSULIN RESISTANCE AND VASCULAR COMPLICATIONS IN TYPE 2 DIABETES', ALEXMED ePosters, 7(1), pp. 8-9. doi: 10.21608/alexpo.2025.352132.2063
Morsy, E., Amin, N., Kassab, H., Ali Khalifa Mostafa, R. URINARY C PEPTIDE/ CREATININE RATIO AND ITS RELATION TO INSULIN RESISTANCE AND VASCULAR COMPLICATIONS IN TYPE 2 DIABETES. ALEXMED ePosters, 2025; 7(1): 8-9. doi: 10.21608/alexpo.2025.352132.2063

URINARY C PEPTIDE/ CREATININE RATIO AND ITS RELATION TO INSULIN RESISTANCE AND VASCULAR COMPLICATIONS IN TYPE 2 DIABETES

Article 1, Volume 7, Issue 1, January 2025, Page 8-9  XML
Document Type: Preliminary preprint short reports of original research
DOI: 10.21608/alexpo.2025.352132.2063
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Authors
Eman Youssef Morsy1; Noha Amin2; Heba Sadek Kassab3; Rowan Khalifa Ali Khalifa Mostafa email 1
1Department of Internal Medicine Diabetes and Metabolism, Faculty of Medicine, Alexandria University
2Department of Internal Medicine, Faculty of Medicine, Alexandria University
3Department of Internal Medicine, Faculty of Medicine, Alexandria University, Egypt
Abstract
INTRODUCTION:
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance (IR) which leads overtime to hyperglycemia and progressive beta cell dysfunction. IR is a potent risk factor for vascular complications of diabetes including macro and microvascular complications, which contribute significantly to morbidity and mortality. Urinary c peptide, a byproduct of insulin secretion, serves as a reliable biomarker for beta cell function due to its stability in urine and it is easy to collect. When normalized to creatine levels, the urinary c peptide creatinine ratio (UCPCR) provides a simple, noninvasive measure of endogenous insulin secretion. Close correlations between serum C-peptide, and UCPCR have been shown. And since, high serum C-peptide concentration is a strong indicator of metabolic syndrome and IR, this suggests that UCPCR could be a promising marker for assessing IR.

AIM OF THE WORK:
The aim of the present study was to assess urinary c peptide /creatinine ratio in patients with T2DM and its relation to insulin resistance and vascular complications.
Keywords
UCPCR; IR; T2DM
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