EVALUATION OF ESTROGEN AND PROGESTERONE RECEPTORS STATUS IN ENDOMETRIOID & NON-ENDOMETRIOID ENDOMETRIAL CANCER.

Document Type : Preliminary preprint short reports of original research

Authors

1 Obstetrics and gynecology faculty of medicine

2 Department of Obstetrics and Gynecology, Faculty of Medicine, Alexandria University

3 Department of Pathology, Alexandria Faculty of Medicine, Alexandria University

Abstract

A change in the estrogen and progesterone balance toward a more hyperestrogenic state raises the risk of EC. EC is classified as either estrogen-dependent (endometrioid carcinoma; EEC) or non-estrogen-dependent (non-endometrioid carcinoma; non-EEC). EECs are more prevalent, representing 80% of EC patients. Non-EECs are rarer.
In the literature, the best-established predictive indicators for EC are the estrogen receptor (ER) and the progesterone receptor (PR). Most of ECs are ER and PR-positive. It was hypothesized that EEC and non-EEC would have distinct ER or PR positivities. Other research, however, proposed that the subtypes of ECs share a number of risk variables and that the non-EEC would not be entirely estrogen-independent. Herein, this comparative study intended to detect the presence of ER or PR in endometrium in both endometrioid and non-endometrioid EC.

AIM OF THE WORK:
The aim of this study was to detect the presence of ER or PR in endometrium in both endometrioid and non-endometrioid endometrial cancer.

Keywords

ALEXMED ePosters
Volume 6, Issue 4
September 2024
Pages 100-101

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