ASSOCIATION OF IP6K3 GENE SNP rs791903 AND HASHIMOTO’S THYROIDITIS IN A COHORT OF EGYPTIAN PATIENTS

Document Type : Preliminary preprint short reports of original research

Authors

1 Department of Clinical and Chemical Pathology, Faculty of Medicine, Alexandria University

2 Department of Clinical and Chemical Pathology3, Faculty of Medicine, Alexandria University

3 Department of Internal Medicine, Faculty of Medicine, Alexandria University

Abstract

Introduction :
Hashimoto’s thyroiditis (HT) is an autoimmune thyroid disorder (AITD) characterized by chronic lymphocytes infiltration and proliferation in the thyroid gland resulting in progressive damage of the gland with release of thyroid peroxidase and thyroglobulin immunoglobulin. Etiology of HT is multifactorial and still unclear. However, the probability of developing HT has both environmental and genetic influence with the latter been more prominent. The study on pathogenetic mechanics has revealed various genes involved in development of HT, such as those coding the Human Leukocyte Antigen (HLA) complex; commonly, HLA-B* 46:01, HLA-A* 02:07 and HLA-DRB4. There is emerging evidence on the role of single nucleotide polymorphisms (SNPs) in the predisposition to HT. A genome-wide association study (GWAS) done on Croatian population found rs791903 inside inositol hexakisphosphate kinase 3 (IP6K3) gene as a candidate for HT predisposition in caucasian population. There exist a few studies done on this gene in other nationalities besides Caucasians.

Aim of the Study:
The aim of this study is to investigate the association of IP6K3 gene SNPs variant rs791903 in Hashimoto’s thyroiditis in a cohort of Egyptian subjects.

Keywords

ALEXMED ePosters
Volume 6, Issue 4
September 2024
Pages 86-87

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