CORRELATION OF MISMATCH REPAIR DEFICIENCY WITH HISTOPATHOLOGICAL SUBTYPES AND CLINICAL OUTCOME IN ENDOMETRIAL CANCER

Document Type : Preliminary preprint short reports of original research

Authors

1 Department of Oncology and Nuclear Medicine, Faculty of Medicine, Alexandria University

2 Department of Clinical Oncology, Faculty of Medicine, University of Alexandria

3 Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Alexandria University

4 Department of Obstetrics and Gynecology, Faculty of Medicine, Alexandria University

Abstract

Endometrial carcinoma (EC) is the most common uterine cancer and the second most frequent gynecological malignancy in Egypt and Worldwide. With the recognition of its four molecular subtypes, EC treatment strategies have changed globally, and molecular profiling is now an essential part of clinical judgment, especially for patients with POLE and p53 mutations. Contrary, Mismatch Repair Deficiency (MMRd) being the second most common and aggressive subtype of EC due to its heterogeneity, its clinical features and oncological outcomes remain controversial worldwide. In North Africa and Africa in general not only the behavior of MMRd group is disagreeable but also we still have a crucial knowledge gap regarding EC molecular profiling which is highlighted by lack of data.

Aim of the work:
To correlate MMRd and clinicopathological factors in endometrial cancer (EC) and assess the impact of MMRd on oncological outcomes in EC patient.

Methods:
This retrospective study included 43 patients diagnosed with endometrial cancer and treated at the Alexandria Clinical Oncology Department between 2020 and 2022. MMR status was assessed using immunohistochemistry, and the results were statistically correlated with clinical presentation, tumor pathological characteristics, and patient outcomes.

Keywords

ALEXMED ePosters
Volume 6, Issue 4
September 2024
Pages 83-84

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