THE EFFICACY OF TOPICAL METFORMIN VERSUS ADAPALENE IN PATIENTS WITH MILD AND MODERATE ACNE VULGARIS

Document Type : Preliminary preprint short reports of original research

Authors

1 Department of Dermatology, Venerology and Andrology, Faculty of Medicine, Alexandria University

2 Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Alexandria University

3 Department of Medical Physiology, Faculty of Medicine, University of Alexandria

4 Department of Dermatology, Venereology and Andrology,Faculty of Medicine, Alexandria University

Abstract

-Introduction
Acne vulgaris is one of the most common skin disorders in which various factors are involved in its pathogenesis. The major pathogenic factors involved are hyperkeratinization, obstruction of sebaceous follicles resulting from abnormal keratinization of the infundibular epithelium, stimulation of sebaceous gland secretion by androgens, and microbial colonization of pilosebacous units by propionibacterium acnes which promote perifollicular inflammation .
Investigations of intracellular signaling pathway suggested that over expression of mTORC1 complex leads to increased sebum production and altered keratinization; therefore it has an important role in acne pathogenesis. Although metformin is an antidiabetic drug , it has been found to play an important role in a number of cutaneous disorders . Metformin is able to suppress m TORC over expression through AMPK (adenosine monophosphate activated 4. protein kinase) activation , so applying it topically on acne lesions may lead to relief of symptoms.
-Aim
To investigate the effect of topical metformin alone, topical adapalene alone compared with combination of topical metformin and adapalene in patients with mild to moderate acne vulgaris.

Keywords

ALEXMED ePosters
Volume 6, Issue 4
September 2024
Pages 70-71

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