STUDY OF DEMOGRAPHIC ASPECTS, CLINICAL CHARACTERISTICS AND THERAPEUTIC APPROACHES IN PSORIATIC ARTHRITIS PATIENTS

Document Type : Preliminary preprint short reports of original research

Authors

1 Professor of Internal Medicine, Faculty of Medicine, University of Alexandria.

2 Internal Medicine Department, Faculty of Medicine, Alexandria University

3 Assistant professor of Internal Medicine, Faculty of Medicine, University of Alexandria

4 Professor of Dermatology, Venerology and Andrology, Faculty of Medicine Alexandria University

5 Department of Internal Medicine, Alexandria Faculty of Medicine

Abstract

INTRODUCTION
Psoriatic arthritis (PsA) is a chronic inflammatory arthropathy associated with psoriasis. It was first described as a variant of rheumatoid arthritis (RA). However, PsA is considered a unique arthropathy with distinct clinical and radiological features.
Diagnosis is most commonly made by identifying inflammatory musculoskeletal features in the joints, entheses or the spine in the presence of skin and/or nail psoriasis.
PsA is associated with extra-articular manifestations including uveitis and inflammatory bowel disease. PsA is also associated with several chronic conditions, which may affect lifespan and quality of life (QoL). Obesity is particularly common in patients with PsA, and is significantly more prevalent than in patients with psoriasis or rheumatoid arthritis and the general population. In addition, PsA is associated with an increased prevalence of cardiovascular risk factors such as hypertension, hyperlipidemia, type 2 diabetes mellitus, and the combination of these (the metabolic syndrome). In addition, depression and anxiety are common in patients with PsA which have a substantial impact on treatment outcomes and, therefore, these comorbidities should be identified and managed so as to improve outcomes.

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