Document Type : Preliminary preprint short reports of original research
Authors
1
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Alexandria
2
Department of Obstetrics and Gynecology, Faculty of Medicine, Alexandria University
3
Radiodiagnosis, Faculty of Medicine , Alexandria University , Alexandria , Egypt
4
Department of Clinical and Chemical Pathology, Faculty of Medicine, University of Alexandria.
5
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Alexandria.
Abstract
The most common tumor in the female genital system globally is endometrial cancer, with a global rise in incidence as well as disease-related morbidity and mortality. EC has diverse histological subtypes and molecular characteristics.
In the past, EC was divided into two types: Type I is characterized by unopposed estrogen stimulation and includes more common low-grade cells with a favorable prognosis, and Type II, which is not estrogen-driven, includes less prevalent high-grade cells with a poor prognosis. Type I ECs consists of grade I or grade II endometrioid adenocarcinomas, while Type II ECs consist of serous clear cell, undifferentiated, carcinosarcomas, and grade III endometrioid adenocarcinomas.
Chitinase-3 like-protein-1, also known as breast regression protein 39 (BRP-39) or YKL-40 in humans, is a common CLP found in both prokaryotes and eukaryotes. The three N-terminal amino acid residues—tyrosine (Y), lysine (K), and leucine (L)—that are present in the secreted form and have a molecular weight of 40 kDa have earned it the designation YKL-40.
Aim of the work:
The aim of this study was to compare YKL-40 as a marker for lymph node affection in patients with endometrial carcinoma to the available imagining study (Ct staging and / or MRI pelvis) and in relation to the histopathological examination of resected lymph nodes done at gyne-oncology unit at El Shatby Maternity University Hospital from January 2023 till May 2024.
Keywords
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