THE ASSOCIATION BETWEEN THE LEVEL OF VITAMIN K2 IN BLOOD AND THE SEVERITY OF SYMPTOMS IN IDIOPATHIC PARKINSONIAN PATIENTS

Document Type : Preliminary preprint short reports of original research

Authors

1 Department of Neuropsychiatry ,Faculty of Medicine, University of Alexandria.

2 Department of Neuropsychiatry, Faculty of Medicine, Alexandria University.

3 Department of Medical Biochemistry, Alexandria Faculty of Medicine

4 Department of Neuropsychiatry, Faculty of Medicine, Alexandria University

Abstract

INTRODUCTION:
Parkinson's disease (PD) is a progressive neurodegenerative disorder that might result in death, and affects ~1–3% of the global population aged from 40 years to above 60 years. There are two forms of PD: familial; genetically inherited in either an autosomal dominant or recessive manner, and sporadic (idiopathic); believed to develop from gene-environment interactions. Idiopathic Parkinson’s disease (IPD) is the most common neurodegenerative disorder after Alzheimer’s disease. The major motor symptoms of IPD are resting tremor, bradykinesia, rigidity, and postural reflex disturbance. Apart from these dopaminergic motor symptoms, non-motor symptoms also develop secondary to serotonergic, noradrenergic, cholinergic, and autonomic nervous system involvement. Non-motor symptoms include major neuropsychiatric symptoms such as cognitive dysfunction, autonomous disorders, sleep disorders, and sensory symptoms. Underlying many of the motor symptoms of PD is the selective loss of dopaminergic neurons of the substantia nigra pars compacta and their principal axon projections to the striatum.
AIM OF THE WORK:
The aim of this study was to investigate the association between circulating level of vitamin K2 and the severity of symptoms in idiopathic Parkinson’s Disease patients.

Keywords

ALEXMED ePosters
Volume 6, Issue 4
September 2024
Pages 49-50

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