SERUM LEVELS OF INTERLEUKIN-17, D-DIMER, IMMUNOGLOBULIN-E AND AUTOLOGOUS SERUM SKIN TEST AS SEVERITY MARKERS IN CHRONIC SPONTANEOUS URTICARIA

Document Type : Preliminary preprint short reports of original research

Authors

1 Dermatology, Venereology and Andrology, Faculty of Medicine, Alexandria University.

2 Department of Dermatology, Venereology, and Andrology, Faculty of Medicine, Alexandria University, Egypt.

3 Department of Clinical & chemical Patholohy**, Faculty of Medicine, Alexandria University, Egypt

4 Dermatology, Venereology and Andrology, Faculty of Medicine, Alexandria University

Abstract

INTRODUCTION
Chronic spontaneous urticaria (CSU) is a skin disorder, in which the spontaneous appearance of wheals (hives), may be or not accompanied by angioedema, that remains above six weeks on most days of the week without any apparent trigger is characteristic. At any time, the prevalence of CSU has been suggested to be 0.5% to 1%.
The evaluation of disease activity is mainly based on medical history and clinical assessment, besides, using a number of validated questionnaires, including urticarial activity score (UAS7) and angioedema activity score (AAS). However, these questionnaires are subjective with a retrospective design. Accordingly, there is an urgent need for objective measurable indicators to assess the disease activity and monitor the treatment response.
Owing to the suggested autoimmune nature of CSUthat is defined by functional Immunoglobulin (Ig) auto antibodies that are present in the blood and target either IgE or the alpha chain of IgE receptor, IgE was investigated to assess its actual role in the disease severity and activity. Additionally, the Autologous Serum Skin Test (ASST), a simple, office-based screening test for serum auto-reactivity in patients with CSU that detects auto antibodies was assessed.
The imbalance between T lymphocyte subgroups and cytokines is one of the underlying causes of the majority of autoimmune and allergy disorders. In many autoimmune diseases, including CSU, elevated Interlukin-17 (IL-17) was reported.

Keywords

ALEXMED ePosters
Volume 6, Issue 4
September 2024
Pages 41-42

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