PROGESTERONE PRIMED STIMULATED CYCLES VERSUS FIXED ANTAGONIST PROTOCOL IN INTRACYTOPLASMIC SPERM INJECTION CYCLES

Document Type : Preliminary preprint short reports of original research

Authors

1 Obstetrics and Gynecology Department, Faculty of Medicine, Alexandria University

2 Department of Obstetrics and Gynecology, Alexandria Faculty of Medicine, Alexandria University

3 ob/gyn, faculty of medicine, alexandria university

4 Department Of Obstetrics & Gynecology, Faculty of Medicine, Alexandria University

Abstract

INTRODUCTION
To maximize the likelihood of a successful outcome, the procedures utilized for ovulation stimulation during assisted reproductive techniques (ART) attempt to retrieve the maximum number of oocytes. To prevent an early luteinizing hormone (LH) peak and ovulation before oocyte extraction, gonadotropin-stimulating hormone (GnRH) antagonists or agonists are frequently added. Available evidence suggests that progesterone-primed ovarian stimulation (PPOS) provides a similar number of oocytes retrieved and pregnancy rate per transfer compared with the GnRH antagonist protocol.

AIM OF THE WORK
This study aims to compare progesterone-primed stimulated cycles and fixed antagonist protocol in intracytoplasmic sperm injection (ICSI) procedures when applying the freeze-all and blastocyst transfer strategy. Primary aim: Clinical Pregnancy Rate at the first ET (Blastocyst).
Secondary aim: The mean metaphase of meiosis II (MII) retrieved oocytes, rate of fertilization, rate of blastocyst formation, average length of stimulation, and average gonadotropin dosage.

PATIENTS& METHODS
This prospective randomized controlled trial (RCT) included 2 groups of 180 women, (90 each); recruited from the infertility unit at El Shatby University Hospital in collaboration with private IVF centers in Alexandria. All patients were undergoing ICSI and frozen embryo transfer (FET). Patients were subjected to either; group I [Progesterone primed ovarian stimulation (PPOS)] or group II [Gonadotropin-releasing hormone antagonist (GnRH anta) protocol], through a random computerized allocation system; to compare between progesterone primed stimulated cycles and fixed antagonist protocol in intracytoplasmic sperm injection (ICSI) procedure when the freeze-all and blastocyst transfer strategy is applied.

Keywords

ALEXMED ePosters
Volume 6, Issue 4
September 2024
Pages 37-38

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