ASSESSMENT OF TRANSEPIDERMAL DELIVERY OF PLATELET-RICH PLASMA (PRP) ENHANCED NANOFAT TREATMENT IN ATROPHIC POST BURN SCARS .

Document Type : Preliminary preprint short reports of original research

Authors

1 Department of Plastic and Reconstructive Surgery, Faculty of Medicine, Alexandria University

2 surgery ,faculty of medicine ,alexandria

3 Department of Surgery, Faculty of Medicine, Alexandria University, Egypt.

Abstract

Introduction
Burn injuries are a major global public health concern, impacting millions annually. Despite advances in acute care boosting survival rates, burn scars lead to long-lasting physical and psychological effects. One of the consequences of burns is atrophic scars that result in functional limitations and cosmetic issues, affecting self-esteem. They happen due to disruption of healing process and inadequate collagen restoration, giving the scar the characteristic sunken appearance. Managing these scars is multifaceted, requiring aesthetic and functional considerations. Various treatment strategies have been researched however this study focuses on a novel approach utilizing Platelet-Rich Plasma (PRP) combined with microneedling and nanofat grafting to enhance the healing of atrophic post-burn scars. Each therapeutic modality targets different aspects of scar pathology, aiming for improved clinical outcomes by promoting collagen formation and skin regeneration while addressing the aesthetic concerns associated with scars. The treatment results are assessed by POSAS Scar scale and histologically.

Keywords