THE EFFECT OF MIDODRINE ON THE DURATION OF INTRAVENOUS VASOPRESSORS IN SEPTIC SHOCK GUIDED BY ELECTRICAL CARDIOMETRY

Document Type : Preliminary preprint short reports of original research

Authors

1 Critical Care Medicine Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt

2 Department of Critical Care Medicine, Faculty of Medicine, Alexandria University

3 Department of Critical Care Medicine Faculty of Medicine Alexandria University

Abstract

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection;it is characterized by an underlying circulatory, cellular and metabolic abnormality.
Septic shock is among the most common reasons for admission to ICU throughout the world,and is associated with a higher risk for mortality and morbidity.
IV vasopressors are a crucial component in the management of persistent severe hypotension and shock state, the ongoing administration of IV vasopressors, even at low rate, prevent transferring patients out of the ICU which has many economic burdens. prolonged use of IV vasopressor may also increase the risk of peripheral and visceral ischemia, and may also lead to direct cardiac toxicity.
Midodrine is a peripherally acting alpha-1 adrenergic agonist;it causes modest elevation in standing and supine pressure.

AIMOF THE WORK:
The aim of this study was to evaluate whether oral administration of midodrine is an effective adjunct to allow early liberation of IV vasopressors and allow earlier discharge from ICU compared to control patients.

Keywords

ALEXMED ePosters
Volume 6, Issue 4
September 2024
Pages 20-21

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