Second Trimester Serum Calprotectin in prediction of early onset Preeclampsia

Document Type : Preliminary preprint short reports of original research

Authors

1 Department of Obstetrics and Gynecology, Faculty of Medicine, Alexandria University

2 Department of Obstetrics and Gynecology, Faculty of Medicine, Alexandria University, Egypt

3 Department of Obstetrics and Gynecology, Faculty of Medicine

4 Department of Obstetrics and Gynecology faculty of medicine Alexandria University

Abstract

Preeclampsia is a pregnancy-induced syndrome, characterized by hypertension and proteinuria, affecting 3% to 5% of pregnancies.
Maternal endothelial dysfunction, inflammation, and leukocyte activation are part of the pathophysiology and circulating factors originating from the uteroplacental circulation are probably essential in the clinical development of preeclampsia.
Calprotectin is released by activated neutrophils. Elevated levels of calprotectin in plasma have been found in inflammatory states, autoimmune diseases, and infections. As well as being a marker of inflammation, calprotectin has antimicrobial, cytotoxic, and cytokine-like effects, and is proposed to be an important mediator with regulatory functions in inflammatory reactions.
AIM OF THE WORK:
The aim of the study was to evaluate the association of serum calprotectin in early second trimester between 14th to 16th weeks and development of early onset preeclampsia < 34wks.
PATIENTS AND METHODS:
This is a prospective observational study will be conducted on 60 pregnant females at gestational age 14th to 16th weeks attending obstetrics clinic of ELShatby university hospital, after approval of the local Ethical committee and having informed written consent for every female included in the study.
All patients were subjected to complete history taking, Thorough examination with careful measurement of blood pressure starting from 16-14 wks, Routine investigations including CBC, Liver functions, Renal functions, coagulation profile, HbA1c,Urine analysis and serum calprotectin.

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ALEXMED ePosters
Volume 6, Issue 4
September 2024
Pages 7-8

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