GROWTH DIFFERENTIATION FACTOR-8 EFFECT ON PROGESTERONE LEVELS DURING CONTROLLED OVARIAN STIMULATION IN INTRACYTOPLASMIC SPERM INJECTION

Document Type : Preliminary preprint short reports of original research

Authors

1 Department of Obstetrics and Gynecology, Faculty of Medicine, Alexandria University

2 Department of Clinical and Chemical pathology, Faculty of Medicine, Alexandria University

3 Department of Obstetrics and Gynecology, Alexandria Faculty of Medicine, Alexandria University

4 Department of Obstetrics and Gynecology, Faculty of medicine, Alexandria University

Abstract

Intracytoplasmic sperm injection includes ovarian stimulation to retrieve mature oocytes, fertilize them by sperms and then embryo transfer after endometrial preparation.GDF-8 is a growth factor belonging to the transforming growth factor- β (TGF-β) superfamily that found to be highly expressed in the female reproductive system in addition to its first discovered site of release from myocytes and showed to have a dynamic trend, regulatory role and negative correlation with progesterone serum levels during controlled ovarian stimulation (COS).
Aim:
The aim of this study was to investigate the role of GDF-8 in regulating progesterone levels during controlled ovarian stimulation in patients undergoing IVF-ICSI- ET and evaluate its effect on pregnancy rate.
Patients and Methods:
42 women undergoing intracytoplasmic sperm injection are enrolled in a prospective cohort study. Patients are selected with the fulfillment of the inclusion criteria.
GDF-8 and progesterone (P4) serum levels both were measured in this study at 3 different time points during COS, human chorionic gonadotropin (hCG) administration day, oocyte pick up (OPU) day and 14 days after embryo transfer.

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