THE POSSIBLE PROTECTIVE EFFECT OF VITAMIN E AND MELATONIN ON CYCLOPHOSPHAMIDE INDUCED OVARIAN FAILURE IN ADULT FEMALE BLACK MICE

Document Type : Preliminary preprint short reports of original research

Authors

1 Department of Human Anatomy and Embryology, Faculty of Medicine, Alexandria University

2 Department of Pathology, Faculty of Medicine- Alexandria University

3 Human Anatomy and Embryology, Faculty of Medicine, Alexandria University, Egypt

Abstract

Introduction:
Premature ovarian failure is a common condition and stands for cessation of the ovarian function in women before the age of 40 years. Amenorrhea is the common feature of premature ovarian failure.Cyclophosphamide has very toxic effect on the ovaries. It disrupts the follicular reserve with reduction in the number of dominant primordial follicles and accelerates follicular atresia by causing follicular apoptosis which causes ovarian dysfunction.Vitamin E works as a chain breaking antioxidant which protects membranes of cells. Exogenous melatonin pretreatment lowers oxidative stress caused by cyclophosphamide.
Aim:
The aim of this work was to study the potential protective role of vitamin E and / or melatonin on the ovarian structure in the ovarian failure induced by cyclophosphamide in adult female black mice.
Material and methods:
The study was carried out on 36 adult female black mice obtained from the Animal House Center, Anatomy department, Faculty of Medicine, Alexandria University.

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