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Kelada, M., Metwally, E., Ahmed Zaki, I., Ayoub, M., Youssef Menesy, R. (2024). THE POSSIBLE PROTECTIVE EFFECT OF VITAMIN E AND MELATONIN ON CYCLOPHOSPHAMIDE INDUCED OVARIAN FAILURE IN ADULT FEMALE BLACK MICE. ALEXMED ePosters, 6(3), 14-15. doi: 10.21608/alexpo.2024.303157.1884
Melad Naim Bushra Kelada; Elsayed Metwally; Inass Ibrahim Ahmed Zaki; Mohamed Gamal Ayoub; Reham Abdelfatah Youssef Menesy. "THE POSSIBLE PROTECTIVE EFFECT OF VITAMIN E AND MELATONIN ON CYCLOPHOSPHAMIDE INDUCED OVARIAN FAILURE IN ADULT FEMALE BLACK MICE". ALEXMED ePosters, 6, 3, 2024, 14-15. doi: 10.21608/alexpo.2024.303157.1884
Kelada, M., Metwally, E., Ahmed Zaki, I., Ayoub, M., Youssef Menesy, R. (2024). 'THE POSSIBLE PROTECTIVE EFFECT OF VITAMIN E AND MELATONIN ON CYCLOPHOSPHAMIDE INDUCED OVARIAN FAILURE IN ADULT FEMALE BLACK MICE', ALEXMED ePosters, 6(3), pp. 14-15. doi: 10.21608/alexpo.2024.303157.1884
Kelada, M., Metwally, E., Ahmed Zaki, I., Ayoub, M., Youssef Menesy, R. THE POSSIBLE PROTECTIVE EFFECT OF VITAMIN E AND MELATONIN ON CYCLOPHOSPHAMIDE INDUCED OVARIAN FAILURE IN ADULT FEMALE BLACK MICE. ALEXMED ePosters, 2024; 6(3): 14-15. doi: 10.21608/alexpo.2024.303157.1884

THE POSSIBLE PROTECTIVE EFFECT OF VITAMIN E AND MELATONIN ON CYCLOPHOSPHAMIDE INDUCED OVARIAN FAILURE IN ADULT FEMALE BLACK MICE

Article 1, Volume 6, Issue 3, July 2024, Page 14-15  XML
Document Type: Preliminary preprint short reports of original research
DOI: 10.21608/alexpo.2024.303157.1884
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Authors
Melad Naim Bushra Kelada1; Elsayed Metwally1; Inass Ibrahim Ahmed Zaki2; Mohamed Gamal Ayoub3; Reham Abdelfatah Youssef Menesy email 1
1Department of Human Anatomy and Embryology, Faculty of Medicine, Alexandria University
2Department of Pathology, Faculty of Medicine- Alexandria University
3Human Anatomy and Embryology, Faculty of Medicine, Alexandria University, Egypt
Abstract
Introduction:
Premature ovarian failure is a common condition and stands for cessation of the ovarian function in women before the age of 40 years. Amenorrhea is the common feature of premature ovarian failure.Cyclophosphamide has very toxic effect on the ovaries. It disrupts the follicular reserve with reduction in the number of dominant primordial follicles and accelerates follicular atresia by causing follicular apoptosis which causes ovarian dysfunction.Vitamin E works as a chain breaking antioxidant which protects membranes of cells. Exogenous melatonin pretreatment lowers oxidative stress caused by cyclophosphamide.
Aim:
The aim of this work was to study the potential protective role of vitamin E and / or melatonin on the ovarian structure in the ovarian failure induced by cyclophosphamide in adult female black mice.
Material and methods:
The study was carried out on 36 adult female black mice obtained from the Animal House Center, Anatomy department, Faculty of Medicine, Alexandria University.
Keywords
OVARIAN; MICE; CYCLOPHOSPHAMIDE
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