THE THERAPEUTIC EFFECT OF MESENCHYMAL STEM CELLS AND ALFACALCIDOL ON CISPLATIN INDUCED ACUTE NEPHROTOXICITY IN MALE ALBINO RATS.

Document Type : Preliminary preprint short reports of original research

Authors

1 Department of Human Anatomy and Embryology, Faculty of Medicine, Alexandria University.

2 Department of Human Anatomy and Embryology, Faculty of Medicine, Alexandria University

3 Department of histology and cell biology, Faculty of Medicine, Alexandria University.

Abstract

Acute kidney injury (AKI) refers to the rapid decline of renal function, typically resulting from toxic or ischemic insults due to chemotherapy, antibiotics, or infection-related shock. Notably, approximately one-third of patients undergoing cisplatin therapy develop AKI, predominantly due to the nephrotoxicity of cisplatin. Cisplatin, an anti-neoplastic agent used for various solid-organ cancers, has its use limited by nephrotoxicity, a significant adverse effect. Oxidative stress is a crucial mechanism underlying cisplatin-induced AKI, suggesting that antioxidants like vitamin D may mitigate these adverse effects. Stem cells, particularly bone marrow-derived mesenchymal stem cells (BM-MSCs), offer a promising therapeutic approach for renal repair. These undifferentiated cells possess considerable self-renewal and tissue generation capabilities. BM-MSCs can ameliorate renal functional deficits, tubular necrosis, and apoptosis while promoting tubular regeneration, likely through paracrine or endocrine mechanisms rather than direct engraftment.

AIM OF THE WORK:
The aim of the present work was to:
• Study the histological and immunohistochemical changes in a rat model of cisplatin – induced acute nephrotoxicity.
• Study the efficacy of BM -MSCs and alfacalcidol (ALFA) to treat cisplatin-induced acute nephrotoxicity in adult male albino rats.

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