EFFECT OF ORLISTAT ON TESTICULAR PALMITOYL PROTEIN THIOESTERASE 1 AND SEMENOGRAM IN OBESE RATS

Document Type : Preliminary preprint short reports of original research

Authors

1 Department of Dermatology, Venereology and Andrology, Faculty of Medicine, University of Alexandria

2 Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Alexandria University

3 Department of Medical Physiology, Faculty of Medicine, University of Alexandria

4 Department of Pathology, Faculty of Medicine, Alexandria University

Abstract

Obesity is a growing public health issue causing health issues like diabetes, cardiovascular disease, hypertension, and hyperlipidemia and male infertility. It is suggested that obesity negatively impacts sperm function, even if this function does not render obese males infertile. Orlistat is an anti-obesity drug used in the management of obesity and its associated co-morbidities.
-Aim:
To investigate the effect of orlistat (10 mg/kg b.w./day) on testicular PPT1 in high fat diet fed as a marker of infertility induced by obesity, in a rat model.

-Patients and Methods
Experimental animals:32 adult male wistar albino rats, weighted from 120 to 150 g were kept under standard laboratory conditions and randomly divided into group I (n=8): Normal group fed on normal control diet, group II (n=8) fed on high fat diet (HFD) only, group III (n=8) fed on HFD with orlistat for12 weeks (preventive group) and group IV(n=8)fed on high fat diet with orlistat for 6 weeks (from 7th week to 12week) ( treated group).

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