Mohamed, N., Hassan, E., Allam, M., Ibrahim Abd Ellatif, A. (2024). EVALUATION OF MAST CELLS EXPRESSION IN THE SKIN OF PEMPHIGUS VULGARIS AND BULLOUS PEMPHIGOID PATIENTS. ALEXMED ePosters, 6(2), 29-30. doi: 10.21608/alexpo.2024.294365.1851
Nagat Sobhy Mohamed; Eman Mohamad Hassan; Maram Mohammed Naguib Allam; Asmaa Hamada Ibrahim Abd Ellatif. "EVALUATION OF MAST CELLS EXPRESSION IN THE SKIN OF PEMPHIGUS VULGARIS AND BULLOUS PEMPHIGOID PATIENTS". ALEXMED ePosters, 6, 2, 2024, 29-30. doi: 10.21608/alexpo.2024.294365.1851
Mohamed, N., Hassan, E., Allam, M., Ibrahim Abd Ellatif, A. (2024). 'EVALUATION OF MAST CELLS EXPRESSION IN THE SKIN OF PEMPHIGUS VULGARIS AND BULLOUS PEMPHIGOID PATIENTS', ALEXMED ePosters, 6(2), pp. 29-30. doi: 10.21608/alexpo.2024.294365.1851
Mohamed, N., Hassan, E., Allam, M., Ibrahim Abd Ellatif, A. EVALUATION OF MAST CELLS EXPRESSION IN THE SKIN OF PEMPHIGUS VULGARIS AND BULLOUS PEMPHIGOID PATIENTS. ALEXMED ePosters, 2024; 6(2): 29-30. doi: 10.21608/alexpo.2024.294365.1851
EVALUATION OF MAST CELLS EXPRESSION IN THE SKIN OF PEMPHIGUS VULGARIS AND BULLOUS PEMPHIGOID PATIENTS
1Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Alexandria University
2Department of pathology, Faculty of Medicine,University of Alexandria.
Abstract
INTRODUCTION Pemphigus vulgaris (PV) and Bullous pemphigoid (BP) are well-known chronic autoimmune bullous dermatoses in which antibodies are directed against basement membrane zone. Mast cells contribution in inflammatory and autoimmune diseases is recently suggested.
AIM OF THE WORK
The aim of this study was to detect mast cells expression in pemphigus vulgaris and Bullous pemphigoid skin lesions.
PATIENTS
The work protocol were as follow: • Patients were recruited from the Dermatology Outpatient Clinic of the Alexandria Main University Hospital.
This study were conducted on: • 20 pemphigus vulgaris patients (Group I). • 20 Bullous pemphigoid patients (Group II). • 10 healthy persons as control (safety margin of basel cell carcinoma and squamous cell carcinoma patients.
METHODS
Mast cells detection in skin biopsies were done by using immunohistochemical staining for CD117.
Results mast cells showed significant higher presentation of (25-50% involvement) in group I than in group II (60% VS 15% of patients respectively).
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