Mohiedeen, K., Kasem, M., Abdeen Ahmed, N., Zaghloul Taleb, R., Silas, M. (2024). PREDICTIVE AND DIAGNOSTIC ROLE OF CIRCULATING GOLGI PROTEIN-73 AND GLYPICAN-3 PROTEIN FOR CHRONIC VIRAL HEPATITIS ASSOCIATED HEPATOCELLULAR CARCINOMA. ALEXMED ePosters, 6(2), 25-26. doi: 10.21608/alexpo.2024.290679.1846
Khalid Mahmoud Mohiedeen; Mohamed Ahmed Kasem; Nermeen Sherif Abdeen Ahmed; Raghda Saad Zaghloul Taleb; Mariam Abubakar Silas. "PREDICTIVE AND DIAGNOSTIC ROLE OF CIRCULATING GOLGI PROTEIN-73 AND GLYPICAN-3 PROTEIN FOR CHRONIC VIRAL HEPATITIS ASSOCIATED HEPATOCELLULAR CARCINOMA". ALEXMED ePosters, 6, 2, 2024, 25-26. doi: 10.21608/alexpo.2024.290679.1846
Mohiedeen, K., Kasem, M., Abdeen Ahmed, N., Zaghloul Taleb, R., Silas, M. (2024). 'PREDICTIVE AND DIAGNOSTIC ROLE OF CIRCULATING GOLGI PROTEIN-73 AND GLYPICAN-3 PROTEIN FOR CHRONIC VIRAL HEPATITIS ASSOCIATED HEPATOCELLULAR CARCINOMA', ALEXMED ePosters, 6(2), pp. 25-26. doi: 10.21608/alexpo.2024.290679.1846
Mohiedeen, K., Kasem, M., Abdeen Ahmed, N., Zaghloul Taleb, R., Silas, M. PREDICTIVE AND DIAGNOSTIC ROLE OF CIRCULATING GOLGI PROTEIN-73 AND GLYPICAN-3 PROTEIN FOR CHRONIC VIRAL HEPATITIS ASSOCIATED HEPATOCELLULAR CARCINOMA. ALEXMED ePosters, 2024; 6(2): 25-26. doi: 10.21608/alexpo.2024.290679.1846
PREDICTIVE AND DIAGNOSTIC ROLE OF CIRCULATING GOLGI PROTEIN-73 AND GLYPICAN-3 PROTEIN FOR CHRONIC VIRAL HEPATITIS ASSOCIATED HEPATOCELLULAR CARCINOMA
1Department of Tropical Medicine, Faculty of Medicine, Alexandria University
2Department of Clinical & chemical Patholohy**, Faculty of Medicine, Alexandria University, Egypt
Abstract
INTRODUCTION
Viral hepatitis, including Hepatitis B and C, is a significant global health challenge and a leading cause of mortality. In Egypt, approximately eight to ten million people are affected by these viruses, posing a serious public health threat. Chronic viral hepatitis can lead to severe complications, with cirrhosis often emerging after prolonged infection, increasing the risk of advanced liver diseases like hepatocellular carcinoma (HCC). Early detection of HCC is crucial, and current guidelines recommend biannual abdominal ultrasound and AFP testing for at-risk patients, though this method has limitations, including a sensitivity of only 63%.Identifying accurate biomarkers for HCC diagnosis is a priority. Glypican-3 (GPC3) and Golgi Protein 73 (GP73) have shown promise as potential biomarkers. GPC3 is highly expressed in HCC tumors and detectable in serum, while GP73 has demonstrated superior sensitivity to AFP. Despite their potential, further validation is necessary.
AIM The present study aims to assess the serum level of GP73 and GPC-3 as diagnostic biomarkers for HCC in patients with viral hepatitis B and C liver cirrhosis.
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