Evaluation of serum taurine level in patients with endometrial cancer

Document Type : Preliminary preprint short reports of original research

Authors

1 Obstetrics and gynecology faculty of medicine

2 Department of Chemical and clinical Pathology, Faculty of Medicine, University of Alexandria

3 Department of Obstetrics and Gynecology, Faculty of Medicine, Alexandria University

Abstract

Endometrial cancer is the most common type of uterine cancer
Risk factors of endometrial cancer: Obesity, Unopposed estrogen therapy, polycystic ovarian syndrome, Tamoxifen therapy, Hypertension, Diabetes mellitus, Pelvic radiation therapy and endometrial hyperplasia. Abnormal vaginal bleeding is a prevalent symptom in endometrial cancer, affecting roughly 90% of diagnosed patients. Physical examination commonly reveals an obese, hypertensive, postmenopausal woman, although approximately 35% of patients are not obese and show no signs of hyperestrogenism. Developing a screening tool of low cost, high feasibility, and high diagnostic accuracy for endometrial cancer is still a maturing area of research.
Laboratory Testing: Taurine (2-aminoethanesulfonic acid), a naturally occurring amino acid found throughout the body, plays a crucial role in ensuring the proper functioning of the central nervous system, retinal neurons, and cardiac and skeletal muscles. Recent research highlights additional benefits, including anti-inflammatory, antioxidant, and blood sugar control properties. Studies indicate it has the ability to inhibit cancer cell proliferation and induce apoptosis, which is programmed cell death Top of Formin certain cancers, possibly through regulation of proteins involved in cell death pathways. It’s important to note that research on taurine’s antitumor effects is in its early stages. The underlying mechanisms by which taurine exerts these effects are not fully understood. However, this initial research offers promising evidence and warrants further investigation into the potential clinical application of taurine in cancer treatment.

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