PROGNOSTIC VALUE OF DIFFERENTIAL LEUKOCYTIC COUNT IN ST SEGMENT ELEVATION MYOCARDIAL INFARCTION (STEMI) PATIENTS IN THE EMERGENCY DEPARTMENT

Document Type : Preliminary preprint short reports of original research

Authors

1 Cardiology Department, Faculty of Medicine, Alexandria University

2 Department of Surgery , faculty of medicine , Alexandria university

3 Department of Cardiology and Angiology, Faculty of Medicine- Alexandria University

4 Emergency Department, Faculty of Medicine, Alexandria University

Abstract

Introduction:
Acute coronary syndrome (ACS) is the main cause of death in affluent countries and one of the major sources of disease burden in developing countries, myocardial infarction (MI) and unstable angina are both ACS conditions. MI is commonly defined as cardio myocyte death caused by substantial and sustained ischemia due to an imbalance of oxygen supply and demand. ST Segment Elevation Myocardial Infarction (STEMI) is the result of transmural ischemia (ischemia that involves the full thickness of the myocardium). The role of hematologic parameters on cardiovascular disease has been investigated, including several types of inflammatory cells such as neutrophils, lymphocytes, monocytes, eosinophils and basophils associated with coronary heart disease. An increase in white blood cell count (leukocytosis) is associated with increased mortality during acute myocardial infarction (AMI) and represents an independent prognostic factor to develop HF and cardiogenic shock.White blood cell count is independent predictor of infarct size in patients with anterior STEMI undergoing primary PCI. When STEMI is suspected, a 12-lead ECG must be acquired and interpreted as soon as possible at the time of first medical contact to facilitate early STEMI diagnosis and triage. PPCI is the standard of care for patients with STEMI presenting with ongoing chest pain.

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