GERMLINE BREAST CANCER SUSCEPTIBILITY GENES MUTATION(BRCA) AND EXPRESSION OF PROGRAMMED DEATH LIGAND-1(PDL-1) IN TRIPLE-NEGATIVE BREAST CANCER EGYPTIAN PATIENTS AND CORRELATION WITH CLINICOPATHOLOGICAL CHARACTERISTICS

Document Type : Preliminary preprint short reports of original research

Authors

1 Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Alexandria University

2 Department of clinical oncology and nuclear medicine, Faculty of Medicine, Alexandria University

3 Department of Pathology, Faculty of Medicine, Alexandria University

Abstract

Triple-negative breast carcinoma (TNBC) is one of the subtypes of breast cancer, known to have a poor prognosis.The most common risk factor is the family history of breast carcinoma, with germline mutation on BRCA1/2 genes being frequently found in comparison to other subtypes. However, non-metastatic TNBC is highly heterogeneous; two subgroups of patients can be described: on the one hand, patients with high-risk disease, not achieving pathological complete response (pCR) despite intense neoadjuvant treatment, and on the other hand, a second group of patients with good prognosis, achieving pCR with less pre-surgery treatment. There is an ongoing effort to de-escalate and escalate therapy, tailoring treatment better to the patients who need it at the right time.
AIM OF THE WORK:
This study aimed to assess the germline BRCA 1/2 mutation and PD-L1 expression in patients with non-metastatic TNBC presented at the Alexandria Clinical Oncology department. It also sought the correlation of the above biomarkerswith the clinicopathological characteristics and the response to neoadjuvant chemotherapy.

Keywords

ALEXMED ePosters
Volume 6, Issue 1
January 2024
Pages 20-21

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