Hassan Thabet, M., El-Deriny, G., Mikhael, N., Mohamed Ibrahim, W., Elsayed, E. (2023). NORMAL T CELL RECEPTOR EXCISION CIRCLES LEVEL IN HEALTHY FULLTERM AND PRETERM NEONATES AT ALEXANDRIA UNIVERSITY CHILDREN’S HOSPITAL. ALEXMED ePosters, 5(3), 45-46. doi: 10.21608/alexpo.2023.233597.1683
Mohamed Alaa El-Din Hassan Thabet; Ghada Farouk El-Deriny; Neveen Lewis Mikhael; Walaa Mohamed Mohamed Ibrahim; Eman Mohamed Elsayed. "NORMAL T CELL RECEPTOR EXCISION CIRCLES LEVEL IN HEALTHY FULLTERM AND PRETERM NEONATES AT ALEXANDRIA UNIVERSITY CHILDREN’S HOSPITAL". ALEXMED ePosters, 5, 3, 2023, 45-46. doi: 10.21608/alexpo.2023.233597.1683
Hassan Thabet, M., El-Deriny, G., Mikhael, N., Mohamed Ibrahim, W., Elsayed, E. (2023). 'NORMAL T CELL RECEPTOR EXCISION CIRCLES LEVEL IN HEALTHY FULLTERM AND PRETERM NEONATES AT ALEXANDRIA UNIVERSITY CHILDREN’S HOSPITAL', ALEXMED ePosters, 5(3), pp. 45-46. doi: 10.21608/alexpo.2023.233597.1683
Hassan Thabet, M., El-Deriny, G., Mikhael, N., Mohamed Ibrahim, W., Elsayed, E. NORMAL T CELL RECEPTOR EXCISION CIRCLES LEVEL IN HEALTHY FULLTERM AND PRETERM NEONATES AT ALEXANDRIA UNIVERSITY CHILDREN’S HOSPITAL. ALEXMED ePosters, 2023; 5(3): 45-46. doi: 10.21608/alexpo.2023.233597.1683
NORMAL T CELL RECEPTOR EXCISION CIRCLES LEVEL IN HEALTHY FULLTERM AND PRETERM NEONATES AT ALEXANDRIA UNIVERSITY CHILDREN’S HOSPITAL
1Department of Pediatrics , Faculty of Medicine, Alexandria University
2Department of Pediatrics ,Faculty of Medicine, Alexandria University
3Department of Clinical and chemical Pathology , Faculty of Medicine, Alexandria University
Abstract
• Severe combined immunodeficiency disease (SCID) is one of the most severe forms of PIDS, the incidence is found to be 1 in 58,000 live births in the United States with higher incidence of autosomal recessive (AR) SCID in communities in which consanguineous marriage is more frequent. • SCID is characterized by absence of T lymphocytes, and/or deficiencies of B cells, and may also affect natural killer (NK) cells. Infants with SCID appear normal at birth, however, they develop severe infections in the first months of life. • Without curative treatment, in the form of allogeneic hematopoietic stem cell transplantation (HSCT) or in some specific forms of SCID, gene therapy, affected infants die within the first two years of life. • Newborn screening for SCID is particularly important in Middle Eastern countries due to the relatively higher incidence of consanguinity. • T-cell receptor excision circles (TRECs) are small circular DNA fragments formed during development of T-lymphocytes in the thymus and do not multiply during cell division. There fore, TREC is a biomarker of naïve T cells.
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