Elsaid, S., Toppozada, T., Hanafi El Fazary, H., Tohamy Mohamed Emam, A. (2023). ADDING L-CARNITINE AND VITAMIN D TO LETROZOLE IN OVULATION INDUCTION IN PCOS PATIENTS. ALEXMED ePosters, 5(3), 44-45. doi: 10.21608/alexpo.2023.233580.1682
Samir Elsaid; Tarek Mokhtar Hussein Toppozada; Hisham Adel Hanafi El Fazary; Asmaa Sayed Tohamy Mohamed Emam. "ADDING L-CARNITINE AND VITAMIN D TO LETROZOLE IN OVULATION INDUCTION IN PCOS PATIENTS". ALEXMED ePosters, 5, 3, 2023, 44-45. doi: 10.21608/alexpo.2023.233580.1682
Elsaid, S., Toppozada, T., Hanafi El Fazary, H., Tohamy Mohamed Emam, A. (2023). 'ADDING L-CARNITINE AND VITAMIN D TO LETROZOLE IN OVULATION INDUCTION IN PCOS PATIENTS', ALEXMED ePosters, 5(3), pp. 44-45. doi: 10.21608/alexpo.2023.233580.1682
Elsaid, S., Toppozada, T., Hanafi El Fazary, H., Tohamy Mohamed Emam, A. ADDING L-CARNITINE AND VITAMIN D TO LETROZOLE IN OVULATION INDUCTION IN PCOS PATIENTS. ALEXMED ePosters, 2023; 5(3): 44-45. doi: 10.21608/alexpo.2023.233580.1682
ADDING L-CARNITINE AND VITAMIN D TO LETROZOLE IN OVULATION INDUCTION IN PCOS PATIENTS
1Department of Obstetrics and Gynecology, Faculty of Medicine, Alexandria University, Egypt
2Department of Obstetrics and Gynaecology, Faculty of Medicine, Alexandria University
3Department of Obstetrics and Gynecology, Faculty of Medicine, Alexandria University
Abstract
INTRODUCTION Carnitine has been also used in the treatment of insulin resistance. Vitamin D has a physiologic role in reproduction including ovarian follicular development and luteinization through changing anti-müllerian hormone (AMH) signalling, follicle-stimulating hormone sensitivity and progesterone production. OBJECTIVE Investigation of the efficacy of combining l-carnitine with vitamin D added to letrozole in comparison to letrozole only for ovulation induction in infertile women with polycystic-ovarian-syndrome (PCOS) as regards the endometrial thickness, ovulation rate, pregnancy rate, rate of mono-follicular development and time to conception. METHODS During this study, 94 infertile women were enrolled, after consenting each of them and divided into two groups; Regarding first group participants, they received ovulation induction plus oral-carnitine (3g) supplementation combined with 800 IU vitamin D per day for two cycles or till the conception combined with letrozole, while the second group participants received letrozole as 5mg once daily for five days (from day 3 to 7) after spontaneous or progesterone induced bleeding and increased to 7.5mg in the following cycle if ovulation did not occur.
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