Younis, L., Abdo, L., Gaber Mohamed Aly, R., Elbannan, M. (2023). FOXP3 AND CD8 EXPRESSION IN DUCTAL CARCINOMA OF THE BREAST AND ITS RELATION TO THE CLINICOPATHOLOGICAL PARAMETERS. ALEXMED ePosters, 5(3), 2-3. doi: 10.21608/alexpo.2023.221921.1638
Layla Kamal Younis; Layla Ahmed Abdo; Rania Gaber Mohamed Aly; Malak Magdy Elbannan. "FOXP3 AND CD8 EXPRESSION IN DUCTAL CARCINOMA OF THE BREAST AND ITS RELATION TO THE CLINICOPATHOLOGICAL PARAMETERS". ALEXMED ePosters, 5, 3, 2023, 2-3. doi: 10.21608/alexpo.2023.221921.1638
Younis, L., Abdo, L., Gaber Mohamed Aly, R., Elbannan, M. (2023). 'FOXP3 AND CD8 EXPRESSION IN DUCTAL CARCINOMA OF THE BREAST AND ITS RELATION TO THE CLINICOPATHOLOGICAL PARAMETERS', ALEXMED ePosters, 5(3), pp. 2-3. doi: 10.21608/alexpo.2023.221921.1638
Younis, L., Abdo, L., Gaber Mohamed Aly, R., Elbannan, M. FOXP3 AND CD8 EXPRESSION IN DUCTAL CARCINOMA OF THE BREAST AND ITS RELATION TO THE CLINICOPATHOLOGICAL PARAMETERS. ALEXMED ePosters, 2023; 5(3): 2-3. doi: 10.21608/alexpo.2023.221921.1638
FOXP3 AND CD8 EXPRESSION IN DUCTAL CARCINOMA OF THE BREAST AND ITS RELATION TO THE CLINICOPATHOLOGICAL PARAMETERS
1Department of Pathology, Faculty of Medicine, Alexandria University.
2Department of Pathology, Faculty of Medicine, Alexandria University
Abstract
Introduction: Globally, breast cancer is the most frequently diagnosed cancer in women. Tumor microenvironment (TME), soluble, cellular and physical components plays a pivotal role in tumor progression. Tumor infiltrating lymphocytes (TILs( in ductal carcinoma in situ (DCIS), with and without invasive carcinoma is an emerging area of clinical research. Recent studies have linked high FOXP3 expression in T regulatory (Treg) tumor infiltrating lymphocytes (TILs) with higher grade and stage and poor clinical outcome. CD8+ cytotoxic T lymphocytes have antitumor effects by induction of tumor cell cytostasis, apoptosis, angiostasis and macrophage tumoricidal activity.Thus, examination of the balance between CD8+ and FOXP3+ T cells is crucial in breast cancer prognosis. Aim of the Work: The current work was carried out to evaluate the expression of CD8 and FOXP3 in DCIS and invasive breast cancer as well as CD8/FOXP3 ratio in relation to clinicopathological parameters.
Material The present study comprised 70 retrospective cases of breast cancer .Paraffin blocks of these cases were obtained from the archives of the Pathology Department, Faculty of Medicine, Alexandria University, from January 2018 till December 2022.
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