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Ahmed, W., Mehanna, R., Mohamed Metwally, E., Mohamed Hussein, S., Mohamed Kamel Mohamed ElHamamy, R. (2023). EFFECT OF INTRA-ARTICULAR INJECTION OF BONE MARROW DERIVED STEM CELLS VERSUS EXTRACELLULAR VESICLES ON INDUCED KNEE OSTEOARTHRITIS IN RATS. ALEXMED ePosters, 5(2), 24-25. doi: 10.21608/alexpo.2023.216309.1623
Wafaa Abdelrahman Ahmed; Radwa Ali Mehanna; Elsayed Aly Mohamed Metwally; Sally Mahmoud Mohamed Hussein; Rowan Mostafa Mohamed Kamel Mohamed ElHamamy. "EFFECT OF INTRA-ARTICULAR INJECTION OF BONE MARROW DERIVED STEM CELLS VERSUS EXTRACELLULAR VESICLES ON INDUCED KNEE OSTEOARTHRITIS IN RATS". ALEXMED ePosters, 5, 2, 2023, 24-25. doi: 10.21608/alexpo.2023.216309.1623
Ahmed, W., Mehanna, R., Mohamed Metwally, E., Mohamed Hussein, S., Mohamed Kamel Mohamed ElHamamy, R. (2023). 'EFFECT OF INTRA-ARTICULAR INJECTION OF BONE MARROW DERIVED STEM CELLS VERSUS EXTRACELLULAR VESICLES ON INDUCED KNEE OSTEOARTHRITIS IN RATS', ALEXMED ePosters, 5(2), pp. 24-25. doi: 10.21608/alexpo.2023.216309.1623
Ahmed, W., Mehanna, R., Mohamed Metwally, E., Mohamed Hussein, S., Mohamed Kamel Mohamed ElHamamy, R. EFFECT OF INTRA-ARTICULAR INJECTION OF BONE MARROW DERIVED STEM CELLS VERSUS EXTRACELLULAR VESICLES ON INDUCED KNEE OSTEOARTHRITIS IN RATS. ALEXMED ePosters, 2023; 5(2): 24-25. doi: 10.21608/alexpo.2023.216309.1623

EFFECT OF INTRA-ARTICULAR INJECTION OF BONE MARROW DERIVED STEM CELLS VERSUS EXTRACELLULAR VESICLES ON INDUCED KNEE OSTEOARTHRITIS IN RATS

Article 1, Volume 5, Issue 2, April 2023, Page 24-25  XML
Document Type: Preliminary preprint short reports of original research
DOI: 10.21608/alexpo.2023.216309.1623
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Authors
Wafaa Abdelrahman Ahmed1; Radwa Ali Mehanna2; Elsayed Aly Mohamed Metwally3; Sally Mahmoud Mohamed Hussein3; Rowan Mostafa Mohamed Kamel Mohamed ElHamamy email 3
1Human Anatomy and Embryology, Faculty of Medicine, Alexandria University, Egypt
2Department of Human Physiology, Faculty of Medicine, Alexandria University
3Department of Human Anatomy and Embryology, Faculty of Medicine, Alexandria University
Abstract
INTRODUCTION:
Osteoarthritis (OA) is a complex chronic illness that affects joints and causes substantial pain and impairment. It is the most common cause of disability worldwide and is characterized by articular cartilage (AC) degeneration with subchondral bone sclerosis, cyst formation, osteophyte formation, synovial lesions, and alterations in surrounding structures. Osteoarthritis mostly affects persons above the age of 50, with femalepredominance.

AIM OF THE WORK:
The aim of the present work was to study the anatomical and histopathological changes in a rat model of monosodium iodoacetate - induced osteoarthritis and to assess the possible therapeutic effects of intra-articular injection of bone marrow mesenchymal stem cell (BM-MSC) versus extracellular vesicles (EV) in a rat model of MIA induced OA.

SUBJECTS AND METHODS:
In this study we used Monosodium Iodoacetate (MIA) to induce knee osteoarthritis in rats. The current was carried out on 27albino rats. The rats were divided into two healthy male rats (weighing about 30 ± 5 g), to obtain the mesenchymal stem cells, and twenty-five female rats (weighing about 200 ± 20 g) which were considered as the experimental group. The experimental group was then divided into ten rats which served as the control group (group I) which were given free access to water and received a standard diet,
Keywords
BONE MARROW; STEM CELLS; OSTEOARTHRITIS
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