INTRAUTERINE FOLLICULAR FLUID INJECTION: A POTENTIAL NOVEL APPROACH TO IMPROVE THE ENDOMETRIUM

Document Type : Preliminary preprint short reports of original research

Authors

1 Department of Obstetrics and Gynecology Faculty of Medicine

2 Department of Obstetrics and Gynecology, Faculty of Medicine, Alexandria University

3 ob/gyn, faculty of medicine, alexandria university

Abstract

Introduction :
Intracytoplasmic sperm injection (ICSI): involves the injection of a single spermatozoon into an oocyte cytoplasm using a glass micropipette in which the oocyte can be fertilized independently of the morphology and/or motility of the injected spermatozoon. To improve ICSI outcomes, one fundamental problem is the thin endometrium which has been identified as an important factor in implantation failure.
Approaches to Improve Endometrial Receptivity:
 Endometrial Injury.
 Intrauterine Administration of Platelet-Rich Plasma.
 Growth Hormone (GH).
 Follicular fluid intrauterine injection.
Follicular fluid:
It is a complex dynamic biological fluid that surrounds the developing oocyte. Follicular fluid (FF) acts as an important mediator in the communication between cells in the antral follicle while bathing and carrying nutrients to the oocyte. Thus, human FF is a key element to the success of natural fertilization present in every stage of the conception process, from the communication between gametes to the development of fully viable embryos, and a vital component in the occurrence of spontaneous pregnancies.

Keywords