ASSOCIATION OF PLASMA (U2) SMALL NUCLEAR RNA FRAGMENTS AND COLORECTAL CANCER IN A COHORT OF EGYPTIAN PATIENTS

Document Type : Preliminary preprint short reports of original research

Authors

1 clinical and chemical pathology, Alexandria faculty of edicine, Alexandria University, Alexandria, Egypt

2 Clinical and chemical pathology, Alexandria Faculty of medicine, Alexandria University, Alexandria, Egypt

3 Department of Git surgery, faculty of medicine, Alexandria university

4 Department of Clinical and Chemical Pathology, Faculty of Medicine, Alexandria University

Abstract

• Colorectal cancer (CRC) is the third most common malignancy worldwide
• In Egypt, CRC is the 7th commonest cancer.
• The CRC is the second deadliest cancer worldwide.
• Screening for early cancer stages is an effective way to reduce cancer mortality
• Development of new biomarkers for noninvasive screening procedures is aid to early diagnosis of cancers and to help in reducing mortality and morbidity.
• Non-coding RNA is a functional RNA that does not encode a protein
• Non-coding RNAs are classified into small non-coding RNAs such as small nuclear RNA (snRNA) and long non-coding RNAs
• SnRNAs are known as U small nuclear RNA
• U2 snRNA fragments proved to be highly stable in the serum, plasma and other body fluids from cancer patients and could be detected by a simple routine PCR-based assay
• Detection of U2 snRNA fragments in the blood can also hold promise for detecting some cancer types at a curable stage.

Keywords

ALEXMED ePosters
Volume 5, Issue 1
January 2023
Pages 14-15

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