Hahad, D., Dessouky, E., Sabry, A., Mohsen, M. (2023). ASSOCIATION OF PLASMA (U2) SMALL NUCLEAR RNA FRAGMENTS AND COLORECTAL CANCER IN A COHORT OF EGYPTIAN PATIENTS. ALEXMED ePosters, 5(1), 14-15. doi: 10.21608/alexpo.2023.188710.1548
Doaa Ibrahim Hahad; Eman Tayea Dessouky; Ahmed Abdelfattah Sabry; Maha Moustafa Mohamed Mohsen. "ASSOCIATION OF PLASMA (U2) SMALL NUCLEAR RNA FRAGMENTS AND COLORECTAL CANCER IN A COHORT OF EGYPTIAN PATIENTS". ALEXMED ePosters, 5, 1, 2023, 14-15. doi: 10.21608/alexpo.2023.188710.1548
Hahad, D., Dessouky, E., Sabry, A., Mohsen, M. (2023). 'ASSOCIATION OF PLASMA (U2) SMALL NUCLEAR RNA FRAGMENTS AND COLORECTAL CANCER IN A COHORT OF EGYPTIAN PATIENTS', ALEXMED ePosters, 5(1), pp. 14-15. doi: 10.21608/alexpo.2023.188710.1548
Hahad, D., Dessouky, E., Sabry, A., Mohsen, M. ASSOCIATION OF PLASMA (U2) SMALL NUCLEAR RNA FRAGMENTS AND COLORECTAL CANCER IN A COHORT OF EGYPTIAN PATIENTS. ALEXMED ePosters, 2023; 5(1): 14-15. doi: 10.21608/alexpo.2023.188710.1548
ASSOCIATION OF PLASMA (U2) SMALL NUCLEAR RNA FRAGMENTS AND COLORECTAL CANCER IN A COHORT OF EGYPTIAN PATIENTS
1clinical and chemical pathology, Alexandria faculty of edicine, Alexandria University, Alexandria, Egypt
2Clinical and chemical pathology, Alexandria Faculty of medicine, Alexandria University, Alexandria, Egypt
3Department of Git surgery, faculty of medicine, Alexandria university
4Department of Clinical and Chemical Pathology, Faculty of Medicine, Alexandria University
Abstract
• Colorectal cancer (CRC) is the third most common malignancy worldwide • In Egypt, CRC is the 7th commonest cancer. • The CRC is the second deadliest cancer worldwide. • Screening for early cancer stages is an effective way to reduce cancer mortality • Development of new biomarkers for noninvasive screening procedures is aid to early diagnosis of cancers and to help in reducing mortality and morbidity. • Non-coding RNA is a functional RNA that does not encode a protein • Non-coding RNAs are classified into small non-coding RNAs such as small nuclear RNA (snRNA) and long non-coding RNAs • SnRNAs are known as U small nuclear RNA • U2 snRNA fragments proved to be highly stable in the serum, plasma and other body fluids from cancer patients and could be detected by a simple routine PCR-based assay • Detection of U2 snRNA fragments in the blood can also hold promise for detecting some cancer types at a curable stage.