EFFECT OF HELICOBACTER PYLORI ERADICATION ON DIABETES CONTROL AND ALBUMINURIA IN TYPE 2 DIABETIC DYSPEPTIC PATIENTS

Document Type : Preliminary preprint short reports of original research

Authors

1 Department of Internal Medicine, Faculty of Medicine, University of Alexandria, Egypt

2 Department of Internal Medicine, Medical Research Institute, University of Alexandria, Egypt

3 Department of Internal Medicine, Faculty of Medicine, Alexandria University

4 Department of Chemical Pathology, Medical Research Institute, University of Alexandria, Egypt

Abstract

Diabetes mellitus (DM) is a systemic metabolic disorder characterized by hyperglycemia. Diabetes mellitus is common and increasing around the world.
Helicobacter pylori (H.pylori) is a gram negative bacterium that colonises the gastric mucosa. Infection with H. pylori has been known as a global public health issue
H.pylori infection has been linked to a variety of metabolic disorders, most notably DM. Also, some studies have proposed a connection between H.pylori infection and endothelial dysfunction; our theory was that a favorable impact on microalbuminuria and diabetes control could be found after H.pylori eradication.
AIM OF THE WORK
To determine the impact of H.pylori eradication on diabetes control and microalbuminuria in patients with T2DM who have dyspeptic symptoms.
PATIENTS & METHODS:
Our study included 25 patients with T2DM, microalbuminuria and H.pylori positive infection before and after successful eradication of H.pylori. The patients enrolled were subjected to history taking, thorough clinical examination and routine laboratory investigations. Microalbuminuria through urinary albumin/creatinine ratio (UACR), the glycemic control through fasting plasma glucose (FPG), 2-hour plasma glucose (2-h PG) and glycated hemoglobin (HbA1c) level and H.pylori by stool antigen were evaluated.

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