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swelem, R., Ghallab, O., Eldabah, N., Nyae, S. (2022). A STUDY OF EUCHROMATI C HISTONE-LYSINE N-METHYLTRANSFERASE 1 EXPRESSION IN EGYPTIAN CHRONIC LYMPHOCYTIC LEUKAEMIA PATIENTS.. ALEXMED ePosters, 4(4), 50-51. doi: 10.21608/alexpo.2022.182114.1531
rania shafik swelem; Omar Mohamed Ghallab; Nermeen Eldabah; Swaleh Hassan Nyae. "A STUDY OF EUCHROMATI C HISTONE-LYSINE N-METHYLTRANSFERASE 1 EXPRESSION IN EGYPTIAN CHRONIC LYMPHOCYTIC LEUKAEMIA PATIENTS.". ALEXMED ePosters, 4, 4, 2022, 50-51. doi: 10.21608/alexpo.2022.182114.1531
swelem, R., Ghallab, O., Eldabah, N., Nyae, S. (2022). 'A STUDY OF EUCHROMATI C HISTONE-LYSINE N-METHYLTRANSFERASE 1 EXPRESSION IN EGYPTIAN CHRONIC LYMPHOCYTIC LEUKAEMIA PATIENTS.', ALEXMED ePosters, 4(4), pp. 50-51. doi: 10.21608/alexpo.2022.182114.1531
swelem, R., Ghallab, O., Eldabah, N., Nyae, S. A STUDY OF EUCHROMATI C HISTONE-LYSINE N-METHYLTRANSFERASE 1 EXPRESSION IN EGYPTIAN CHRONIC LYMPHOCYTIC LEUKAEMIA PATIENTS.. ALEXMED ePosters, 2022; 4(4): 50-51. doi: 10.21608/alexpo.2022.182114.1531

A STUDY OF EUCHROMATI C HISTONE-LYSINE N-METHYLTRANSFERASE 1 EXPRESSION IN EGYPTIAN CHRONIC LYMPHOCYTIC LEUKAEMIA PATIENTS.

Article 4, Volume 4, Issue 4, December 2022, Page 50-51  XML
Document Type: Preliminary preprint short reports of original research
DOI: 10.21608/alexpo.2022.182114.1531
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Authors
rania shafik swelem1; Omar Mohamed Ghallab2; Nermeen Eldabah3; Swaleh Hassan Nyae email 4
1clinical pathology, faculty of medicine, alexandria university
2Department of Internal Medicine hematology Unit
3khartum Square, Azarita, Alexandria, Egypt
4Clinical and Chemical Pathology, Faculty of Medicine, Alexandria University , Alexandria, Egypt
Abstract
Chronic lymphocytic leukemia is a indolent hematological disorder characterized by monoclonal B lymphocyte proliferation. It is the most common adult leukemia in Western populations and comprises up to 30 percent of leukemias developed world.
Identification of the cases that need early and prompt treatment still leaves many patients with untailored treatment options.
Study of epigenetics in leukemia may provide early identification and effective treatment option. There has been intensive work on the role of various methyltransferases in leukemias, however EHMT1 expression levels in Egyptian patients with CLL, and their prognostic value are still inconclusive.
A previous study have suggested that EHMT1 is over expressed is CLL cases with worse prognosis cytogenetic abnormalities (p = 0.05), however expression level of EHMT1 has not been studied against CD38 and Zap70.
AIM OF WORK:
To study the expression of EHMT1 in newly diagnosed CLL patients and evaluate its role as a prognostic marker for CLL.
Keywords
CLL; EHMT1; EXPRESSION
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