THE VALUE OF IMMUNE INHIBITORY RECEPTOR IMMUNOGLOBULIN-LIKE TRANSCRIPT 3 EXPRESSION IN THE DIAGNOSIS OF ACUTE MYELOID LEUKEMIA WITH MONOCYTIC DIFFERENTIATION

Document Type : Preliminary preprint short reports of original research

Authors

1 Department of Clinical and Chemical Pathology, University of Alexandria

2 department of chemical and clinical pathology, Faculty of medicine.

3 Department of Hematology*, Faculty of Medicine, University of Alexandria

Abstract

Acute myeloid leukemia (AML) represents a heterogeneous disease characterized by clonal proliferation of abnormal blast cells in the bone marrow interfering with the production of normal hematopoietic cells. The 2017 World Health Organization (WHO) classification includes four major entities: AML with recurrent genetic abnormalities, AML with myelodysplasia related changes, therapy-related myeloid neoplasms, and AML-not otherwise specified (NOS). A subset of AML-NOS is AML with monocytic differentiation has a high risk of extra medullary infiltration, high leukocytic count and specific cytogenetic abnormalities. Flowcytometric (FC) immunophenotyping is suited for identification of monocytes by available antibodies such as CD11b, CD13, CD4, CD14, CD15, CD34, CD36, CD64, CD11c and CD117. However, neoplastic monocytes variably express these markers. The ILT3 molecule is a transmembrane protein immune inhibitory receptor expressed by APCs as monocytes and DCs. Therefore, the current study was designed to investigate the usefulness of ILT3 expression to distinguish AML with monocytic differentiation from other types of AML.

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ALEXMED ePosters
Volume 4, Issue 3
September 2022
Pages 32-33

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